Structural cartilage biomarkers in Osteoarthritis (OA) - A Sub-Study of the CAROT Study

One of the characteristics of OA is loss of articular cartilage. The process of cartilage catabolism may happen at different rate, and the question is if different interventions may slow down or stop the process. In a group of overweight OA patients exposed to a substantial weight loss, we are following collagen-II (the major collagen in cartilage) markers, as well as extra-cellular matrix markers from cartilage, to see if the intervention will be reflected in a decrease in cartilage breakdown.