Biological markers in the Evaluation of effects of Treatment in Rheumatoid Arthritis, Psoriatic Arthritis and Osteoarthritis

29.09.2014

Summary

The overall aim is to assess changes in biochemical markers with changes in disease progression, and with treatment, in rheumatoid arthritis, osteoarthritis and psoriatic arthritis.The project consists of several sub-projects: I Pro-inflammatory markers in paired samples from blood and synovial fluid from affected joint – How do these correlate to clinical assessments. II Pro-inflammatory activity of ex-vivo explants of synovial membrane from site-specific biopsies from inflamed joint – How do these correlate to clinical assessments. III Study comparing changes in ultrasound (US) Doppler with changes in plasma Vascular Endothelial Growth Factor (VEGF) and IL-6 in patients with rheumatoid arthritis treated with anti-TNF-α.

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