Asthma in elite athletes--how do we treat it?
Backer, V., aug. 2002, I: Scandinavian journal of medicine & science in sports. 12, 4, s. 195-6 2 s.
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Backer, V., aug. 2002, I: Scandinavian journal of medicine & science in sports. 12, 4, s. 195-6 2 s.
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Jørgensen, H. S., Nakayama, H., Christensen, H. R., Raaschou, H. O., Kampmann, J. P. & Olsen, T. S., 2002, I: Cerebrovascular diseases (Basel, Switzerland). 13, 3, s. 204-9 6 s.
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This study examines blood pressure (BP) and independent factors related to BP in the acute phase of stroke. The study is part of the community-based Copenhagen Stroke Study. In a multivariate regression model we analyzed the impact of clinical and medical factors on admission BP. BP declined with increasing time from stroke onset with a total of 8/4 mm Hg. Independent factors related to diastolic BP were ischemic heart disease (-3.9 mm Hg), male gender (2.2 mm Hg), known hypertension prior to stroke (8.6 mm Hg), and primary hemorrhage (9.7 mm Hg). Independent factors related to systolic BP were age (3.6 mm Hg/10-year increase), atrial fibrillation (-7.2 mm Hg), ischemic heart disease (-6.0 mm Hg), intracerebral hemorrhage (13.3 mm Hg), and known hypertension prior to stroke (16.3 mm Hg). No independent relations were seen between BP and diabetes, claudication, previous stroke, smoking, daily alcohol consumption, initial stroke severity and lesion size. The increase in BP in the acute phase of stroke is a uniform response to the ischemic event per se. BP is not related to stroke severity. Several factors are independently related to the BP level in acute stroke. The clinical significance of this is yet to be tested, but these factors may contribute to the seemingly complex relation between BP and outcome.
Originalsprog | Engelsk |
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Tidsskrift | Cerebrovascular diseases (Basel, Switzerland) |
Vol/bind | 13 |
Udgave nummer | 3 |
Sider (fra-til) | 204-9 |
Antal sider | 6 |
ISSN | 1015-9770 |
DOI | |
Status | Udgivet - 2002 |
Sneppen, S. B., Hoeck, H. C., Kollerup, G., Sørensen, O. H., Laurberg, P. & Feldt-Rasmussen, U., feb. 2002, I: European Journal of Endocrinology. 146, 2, s. 187-95 9 s.
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OBJECTIVE: To evaluate the effect of physiological adult growth hormone (GH) replacement on bones.
DESIGN: Thirty-six prospective severely growth hormone-deficient (GHD) adults (22 females and 14 males) were randomised to either 18 months of GH (0.03 mU/kg/day) or placebo treatment.
METHODS: Bone mineral density and content (BMD, BMC) and body composition were evaluated by dual energy X-ray absorptiometry at baseline and after 6, 12 and 18 months. Serum concentrations of insulin-like growth factor-I (IGF-I), IGF binding protein 3, osteocalcin, carboxyterminal propeptide of type I collagen, carboxyterminal crosslink telopeptide of type I collagen, amino-terminal propeptide of type III procollagen and urine pyridinolin and deoxypyridinolin were determined.
RESULTS: IGF-I levels increased from 63.2 microg/l (+/-10.1) to 193.6 (+/- 25.8) microg/l (mean (+/-s.e.)) (P<0.001 compared with placebo). Markers of bone turnover increased significantly from 142% to 227% of baseline values (all P<0.001 compared with placebo). Body composition changes were an increase of lean body mass and a decrease of fat mass resulting in a reduction of percentage body fat of +/- 1.8 (+/- 3.8) in the GH-treated group vs an increase of 1.0 (+/-2.9)) in the placebo-treated group (P=0.002).
CONCLUSIONS: No significant difference in BMD or BMC between the GH and placebo groups was found after 18 months. At several sites the variances of changes from baseline were significantly greater in the GH than in the placebo group, indicating an impact of the treatment. From baseline to 6 months an insignificant reduction of total BMD was seen while an increase of BMD was found from 6 to 18 months in the GH group compared with the placebo group. This placebo-controlled trial confirmed the longer term open studies on the effect on bones in patients with GHD, with an initial overrepresentation of bone resorption followed by an increase in BMD which at 18 months had reached baseline level.
Originalsprog | Engelsk |
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Tidsskrift | European Journal of Endocrinology |
Vol/bind | 146 |
Udgave nummer | 2 |
Sider (fra-til) | 187-95 |
Antal sider | 9 |
ISSN | 0804-4643 |
DOI | |
Status | Udgivet - feb. 2002 |
Danish Breast Cancer Cooperative Group Tumour Biology Committee, 2002, I: Acta Oncologica. 41, 7-8, s. 695-703 9 s.
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Andersen, G., Christrup, L. L., Sjøgren, P., Hansen, S. H. & Jensen, N.-H., feb. 2002, I: Journal of Pain and Symptom Management. 23, 2, s. 161-4 4 s.
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Thomsen, A. B., Sørensen, J., Sjøgren, P. & Eriksen, J., 2002, I: European Journal of Pain. 6, 5, s. 341-52 12 s.
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Christiansen, S., Eiberg, J. P. & Hansen, M. A., dec. 2002, I: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. 24, 6, s. 555-7 3 s.
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Hansen, H. P., Hovind, P., Jensen, B. R. & Parving, H-H., jan. 2002, I: Kidney International. 61, 1, s. 163-8 6 s.
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Hansen, H. P., Tauber-Lassen, E., Jensen, B. R. & Parving, H-H., jul. 2002, I: Kidney International. 62, 1, s. 220-8 9 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Møller, A., Villebro, N. M., Pedersen, T. & Tønnesen, H., 12 jan. 2002, I: Lancet. 359, 9301, s. 114-7 4 s.
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Originalsprog | Engelsk |
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Tidsskrift | Lancet |
Vol/bind | 359 |
Udgave nummer | 9301 |
Sider (fra-til) | 114-7 |
Antal sider | 4 |
ISSN | 0140-6736 |
DOI | |
Status | Udgivet - 12 jan. 2002 |
Nilsson, F. M., Kessing, L. V., Sørensen, T. M., Andersen, P. K. & Bolwig, T. G., jul. 2002, I: Journal of neurology, neurosurgery, and psychiatry. 73, 1, s. 40-4 5 s.
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OBJECTIVE: To investigate the time relation between dementia and major affective disorders (major depression and mania).
METHODS: Register linkage study of the Danish Hospital Register and the Danish Psychiatric Central Research Register, to establish study cohorts of patients with dementia and control groups (osteoarthritis or diabetes) on first discharge from hospital. Follow up of cohorts was for up to 21 years. Hazard of death was allowed for by the use of competing risks models.
RESULTS: Patients with dementia had an increased risk of being admitted to hospital for major depression or mania during the course of the illness. The incidence remained elevated throughout the rest of the patient's life.
CONCLUSIONS: Patients with dementia have an increased risk of developing depression or mania. Proper treatment of affective disorders in patients with dementia is important in reducing suffering and costs.
Originalsprog | Engelsk |
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Tidsskrift | Journal of neurology, neurosurgery, and psychiatry |
Vol/bind | 73 |
Udgave nummer | 1 |
Sider (fra-til) | 40-4 |
Antal sider | 5 |
ISSN | 0022-3050 |
Status | Udgivet - jul. 2002 |
Backer, V., Nepper-Christensen, S., Ulrik, C. S., von Linstow, M-L. & Porsbjerg, C., aug. 2002, I: Annals of Allergy, Asthma, & Immunology. 89, 2, s. 148-54 7 s.
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Aalbers, R., Ayres, J., Backer, V., Decramer, M., Lier, P. A., Magyar, P., Malolepszy, J., Ruffin, R. & Sybrecht, G. W., maj 2002, I: European Respiratory Journal. Supplement. 19, 5, s. 936-43 8 s.
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Neuenschwander, A. U., Pedersen, J. H., Krasnik, M. & Tønnesen, H., 2002, I: European Journal of Cardio-thoracic Surgery. 22
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Originalsprog | Engelsk |
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Tidsskrift | European Journal of Cardio-thoracic Surgery |
Vol/bind | 22 |
ISSN | 1010-7940 |
Status | Udgivet - 2002 |
Ness, R. B., Cramer, D. W., Goodman, M. T., Kjaer, S. K., Mallin, K., Mosgaard, B. J., Purdie, D. M., Risch, H. A., Vergona, R. & Wu, A. H., 1 feb. 2002, I: American Journal of Epidemiology. 155, 3, s. 217-24 8 s.
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Tønnesen, H., 2002, I: Journal für Anästhesie und Intensivbehandlung.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Originalsprog | Engelsk |
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Tidsskrift | Journal für Anästhesie und Intensivbehandlung |
Status | Udgivet - 2002 |
Bendix, A. F. & Tønnesen, H., 2002, I: Månedsskr Prakt Lægegern. 80
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Originalsprog | Dansk |
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Tidsskrift | Månedsskr Prakt Lægegern |
Vol/bind | 80 |
ISSN | 0373-2746 |
Status | Udgivet - 2002 |
Eyuboglu, S., Angus, G., Patel, B. N., Pareek, A., Davidzon, G., Dunnmon, J. & Lungren, M. P., 2002.
Publikation: Working paper › Preprint
Krarup, C., okt. 2002, I: Current Opinion in Neurology. 15, 5, s. 579-93 15 s.
Publikation: Bidrag til tidsskrift › Review › peer review
Mørch, M. M. & Sjøgren, P., 21 jan. 2002, I: Ugeskrift for Laeger. 164, 4, s. 472-3 2 s.
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