Forbruget af antiastmatisk medicin blandt danske sportsfolk
Lund, T. K., Pedersen, L. & Backer, V., 10 dec. 2007, I: Ugeskrift for Laeger. 169, 50, s. 4355-9 5 s.
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Lund, T. K., Pedersen, L. & Backer, V., 10 dec. 2007, I: Ugeskrift for Laeger. 169, 50, s. 4355-9 5 s.
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von Linstow, M. L. & Andersen, J., 2007, I: Journal of Pediatric Infectious Diseases. 2, 4, s. 247-250 4 s.
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Springborg, L. K., Springborg, J. B. & Thomsen, J., jan. 2007, I: The Journal of laryngology and otology. 121, 1, s. 76-9 4 s.
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Clausen, F. B., Krog, G. R., Rieneck, K. & Dziegiel, M. H., jan. 2007, I: Prenatal Diagnosis. 27, 1, s. 6-10 5 s.
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Dreyer, L., Mellemkjaer, L., Kendall, S., Jensen, B., Danneskiold-Samsøe, B. & Bliddal, H., jan. 2007, I: Journal of Rheumatology. 34, 1, s. 201-6 6 s.
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OBJECTIVE: To analyze whether fibromyalgia (FM) and FM-like symptoms are related to an increased incidence of cancer.
METHODS: We identified 1361 patients referred on suspicion of FM in the period 1984-99 from hospital records. Following the American College of Rheumatology (ACR) criteria, patients were divided into subgroups with and without confirmed FM. The cohort was followed to the end of 1999 and linked to the files of the Danish Cancer Register. Site-specific standardized incidence ratios (SIR) were calculated.
RESULTS: We found no association between FM and cancer in 1132 female patients with confirmed FM at our institution (SIR 1.2, 95% CI 0.8-1.8). In 106 women referred for muscle pain and/or tenderness who did not meet the criteria for FM, an increased overall SIR was observed (SIR 2.5, 95% CI 1.2-4.6), with increased risk for breast cancer (SIR 4.8, 95% CI 1.6-11.3) and lymphatic and hematological cancers (SIR 10.6, 95% CI 1.2-38.2). There were 4 lung cancers in 84 men with confirmed FM (SIR 12.6, 95% CI 3.4-32.4).
CONCLUSION: Neither confirmed FM nor those without confirmed FM predicted cancer. An increased risk of breast cancer was found among those who did not meet the ACR criteria for FM. These patients should be investigated if they develop any new or warning symptoms of malignancy, and treating physicians should be vigilant with screening procedures such as mammography.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Rheumatology |
Vol/bind | 34 |
Udgave nummer | 1 |
Sider (fra-til) | 201-6 |
Antal sider | 6 |
ISSN | 0315-162X |
Status | Udgivet - jan. 2007 |
Bro, S., Binder, C. J., Witztum, J. L., Olgaard, K. & Nielsen, L. B., maj 2007, I: Arteriosclerosis, Thrombosis, and Vascular Biology. 27, 5, s. 1080-6 7 s.
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Qvistgaard, E., Rasmussen, J. H., Laetgaard, J., Hecksher-Sørensen, S. & Bliddal, H., feb. 2007, I: European Spine Journal. s. 277-82
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Lyng, M. B., Laenkholm, A-V., Pallisgaard, N., Vach, W., Knoop, A., Bak, M. & Ditzel, H. J., 2007, I: Cellular oncology : the official journal of the International Society for Cellular Oncology. 29, 5, s. 361-72 12 s.
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Backer, V., Nelbom, B. M., Duus, B. R. & Tønnesen, H., 1 jul. 2007, I: Clinical Respiratory Journal. 1, 1, s. 37-41 5 s.
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Originalsprog | Engelsk |
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Tidsskrift | Clinical Respiratory Journal |
Vol/bind | 1 |
Udgave nummer | 1 |
Sider (fra-til) | 37-41 |
Antal sider | 5 |
ISSN | 1752-6981 |
DOI | |
Status | Udgivet - 1 jul. 2007 |
Mathisen, S. R., Akesson, M., Lindh, M., Ivancev, K. & Resch, T. A., 2007, I: Vascular. 15, 4, s. 211-4 4 s.
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Danneskiold-Samsøe, B., Bartels, E. M. & Dreyer, L., 18 jun. 2007, I: Ugeskrift for læger [online]. 169, 25, s. 2440-2 3 s.
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Many autoimmune diseases like rheumatoid arthritis (RA) show gender differences. RA is triggered by an interaction between genetic, hormonal, environmental and behavioural factors. 75% of cases are women under the age of 60; lover the age 60 the gender ratio is 1:1. Different genotypes predispose for RA. Pregnancy often suppresses RA, as does oral contraception. Lactation, smoking (w), BMI > 30, heavy vibrations and certain dust particles (m) may trigger RA, while the effect of male hormones is uncertain. Future prevention should focus on environment, behavioural factors and genetic profiling.
Bidragets oversatte titel | Gender differences in autoimmune diseases illustrated by rheumatoid arthritis |
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Originalsprog | Dansk |
Tidsskrift | Ugeskrift for læger [online] |
Vol/bind | 169 |
Udgave nummer | 25 |
Sider (fra-til) | 2440-2 |
Antal sider | 3 |
ISSN | 1603-6824 |
Status | Udgivet - 18 jun. 2007 |
Danish Breast Cancer Cooperative Group (DBCG) Tumor Biology Committee, 2007, I: Acta Oncologica. 46, 6, s. 782-91 10 s.
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Jønson, L., Vikesaa, J., Krogh, A., Nielsen, L. K., Hansen, T. VO., Borup, R., Johnsen, A. H., Christiansen, J. & Nielsen, F. C., maj 2007, I: Molecular & cellular proteomics : MCP. 6, 5, s. 798-811 14 s.
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Knudsen, N. Ø., Nielsen, F. C., Vinther, L., Bertelsen, R., Holten-Andersen, S., Liberti, S. E., Hofstra, R., Kooi, K. & Rasmussen, L. J., 2007, I: Nucleic Acids Research. 35, 8, s. 2609-19 11 s.
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Rossen, M., Iversen, K., Teisner, A., Teisner, B., Kliem, A. & Grudzinskas, G., apr. 2007, I: Clinical Biochemistry. 40, 7, s. 478-484 7 s.
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Vejlgaard, T. B., Sjøgren, P. & Maagaard, R., 29 okt. 2007, I: Ugeskrift for Laeger. 169, 44, s. 3737-40 4 s.
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Henriksen, K., Leeming, D. J., Byrjalsen, I., Nielsen, R. H., Sorensen, M. G., Dziegiel, M. H., Martin, T. J., Christiansen, C., Qvist, P. & Karsdal, M. A., jun. 2007, I: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 18, 6, s. 751-9 9 s.
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UNLABELLED: We investigated whether the age of the bones endogenously exerts control over the bone resorption ability of the osteoclasts, and found that osteoclasts preferentially develop and resorb bone on aged bone. These findings indicate that the bone matrix itself plays a role in targeted remodeling of aged bones.
INTRODUCTION: Osteoclasts resorb aging bone in order to repair damage and maintain the quality of bone. The mechanism behind the targeting of aged bone for remodeling is not clear. We investigated whether bones endogenously possess the ability to control osteoclastic resorption.
METHODS: To biochemically distinguish aged and young bones; we measured the ratio between the age-isomerized betaCTX fragment and the non-isomerized alphaCTX fragment. By measurement of TRACP activity, CTX release, number of TRACP positive cells and pit area/pit number, we evaluated osteoclastogenesis as well as osteoclast resorption on aged and young bones.
RESULTS: We found that the alphaCTX/betaCTX ratio is 3:1 in young compared to aged bones, and we found that both alpha and betaCTX are released by osteoclasts during resorption. Osteoclastogenesis was augmented on aged compared to young bones, and the difference was enhanced under low serum conditions. We found that mature osteoclasts resorb more on aged than on young bone, despite unchanged adhesion and morphology.
CONCLUSIONS: These data indicate that the age of the bone plays an important role in controlling osteoclast-mediated resorption, with significantly higher levels of osteoclast differentiation and resorption on aged bones when compared to young bones.
Originalsprog | Engelsk |
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Tidsskrift | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA |
Vol/bind | 18 |
Udgave nummer | 6 |
Sider (fra-til) | 751-9 |
Antal sider | 9 |
ISSN | 0937-941X |
DOI | |
Status | Udgivet - jun. 2007 |
Williams, A. C. D. C. & Amris, K., 15 dec. 2007, I: Pain. 133, 1-3, s. 5-8 4 s.
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Originalsprog | Engelsk |
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Tidsskrift | Pain |
Vol/bind | 133 |
Udgave nummer | 1-3 |
Sider (fra-til) | 5-8 |
Antal sider | 4 |
ISSN | 0304-3959 |
DOI | |
Status | Udgivet - 15 dec. 2007 |
Sjøgren, P., 29 okt. 2007, I: Ugeskrift for Laeger. 169, 44, s. 3735
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Rasmussen, J. N., Rasmussen, S., Gislason, G. H., Abildstrom, S. Z., Schramm, T. K., Torp-Pedersen, C., Køber, L., Diderichsen, F., Osler, M. & Madsen, M., dec. 2007, I: Cardiovascular Drugs and Therapy. 21, 6, s. 449-457 9 s.
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