KRONIK Fremdriftsreformen vil sikre middelmådighed
Fosbøl, E. L., Torp-Pedersen, C., Gislason, G. & Køber, L., jan. 2014, I: Ugeskrift for Laeger. 176, 1
Publikation: Bidrag til tidsskrift › Kommentar/debat › Forskning › peer review
Fosbøl, E. L., Torp-Pedersen, C., Gislason, G. & Køber, L., jan. 2014, I: Ugeskrift for Laeger. 176, 1
Publikation: Bidrag til tidsskrift › Kommentar/debat › Forskning › peer review
Sjøgren, P. & Lindholm, J., 14 apr. 2014, I: Ugeskrift for Laeger. 176, 8
Publikation: Bidrag til tidsskrift › Review › peer review
Østergaard, M., Jacobsson, L., Schaufelberger, C., Hansen, M. S., Bijlsma, J., Dudek, A., Reel-Bakalarska, M., Staalens, F., Haake, R., Sundman-Engberg, B. & Bliddal, H., 2014, I: Scandinavian Journal of Rheumatology. 43, Suppl. 127, s. 14 1 s.
Publikation: Bidrag til tidsskrift › Konferenceabstrakt i tidsskrift › Forskning › peer review
Originalsprog | Engelsk |
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Tidsskrift | Scandinavian Journal of Rheumatology |
Vol/bind | 43 |
Udgave nummer | Suppl. 127 |
Sider (fra-til) | 14 |
Antal sider | 1 |
ISSN | 0300-9742 |
Status | Udgivet - 2014 |
Østergaard, M., Jacobsson, L., Schaufelberger, C., Hansen, M. S., Bijlsma, J., Dudek, A., Rell-Bakalarska, M., Staelens, F., Haake, R., Sundman-Engberg, E. & Bliddal, H., 2014, I: Annals of the Rheumatic Diseases. 73, Suppl. 2, s. 472 1 s.
Publikation: Bidrag til tidsskrift › Konferenceabstrakt i tidsskrift › Forskning › peer review
Originalsprog | Engelsk |
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Tidsskrift | Annals of the Rheumatic Diseases |
Vol/bind | 73 |
Udgave nummer | Suppl. 2 |
Sider (fra-til) | 472 |
Antal sider | 1 |
ISSN | 0003-4967 |
Status | Udgivet - 2014 |
Axelsson, P. B., Bjerrum, F. & Løkkegaard, E. C. L., 24 feb. 2014, I: Ugeskrift for Laeger. 176, 9A, s. V06130415
Publikation: Bidrag til tidsskrift › Review › peer review
Pawar, V., Crull, K., Komor, U., Kasnitz, N., Frahm, M., Kocijancic, D., Westphal, K., Leschner, S., Wolf, K., Loessner, H., Rohde, M., Häussler, S. & Weiss, S., aug. 2014, I: Journal of Internal Medicine. 276, 2, s. 130-9 10 s.
Publikation: Bidrag til tidsskrift › Review › peer review
Kwasny, D., Dimaki, M., Andersen, K. B., Zulfiqar, A., Tumer, Z. & Svendsen, W. E., 23 sep. 2014, 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014. Institute of Electrical and Electronics Engineers Inc., s. 130-134 5 s. 6908775. (9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE-NEMS 2014).
Publikation: Bidrag til bog/antologi/rapport › Konferencebidrag i proceedings › Forskning › peer review
von Linstow, M-L. & Rosenfeldt, V., 2014, I: Case Reports in Pediatrics. 2014, s. 936890
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Kodahl, A. R., Lyng, M. B., Binder, H., Cold, S., Gravgaard, K., Knoop, A. S. & Ditzel, H. J., jul. 2014, I: Molecular Oncology. 8, 5, s. 874-83 10 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Pedersen, M. & Brabrand, M., feb. 2014, I: Ugeskrift for Laeger. 176, 4, s. 345 1 s.
Publikation: Bidrag til tidsskrift › Kommentar/debat › Forskning › peer review
Bliddal, H., Leeds, A. R. & Christensen, R., jul. 2014, I: Obesity reviews : an official journal of the International Association for the Study of Obesity. 15, 7, s. 578-86 9 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Obesity is widely acknowledged as a risk factor for both the incidence and progression of osteoarthritis, and has a negative influence on outcomes. Loss of at least 10% of body weight, coupled with exercise, is recognized as a cornerstone in the management of obese patients with osteoarthritis, and can lead to significant improvement in symptoms, pain relief, physical function and health-related quality of life. However, questions still remain surrounding optimal management. Given the significant health, social and economic burden of osteoarthritis, especially in obese patients, it is imperative to advance our knowledge of osteoarthritis and obesity, and apply this to improving care and outcomes. This paper overviews what is already known about osteoarthritis and obesity, discusses current key challenges and ongoing hypotheses arising from research in these areas, and finally, postulates what the future may hold in terms of new horizons for obese patients with osteoarthritis.
Originalsprog | Engelsk |
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Tidsskrift | Obesity reviews : an official journal of the International Association for the Study of Obesity |
Vol/bind | 15 |
Udgave nummer | 7 |
Sider (fra-til) | 578-86 |
Antal sider | 9 |
ISSN | 1467-7881 |
DOI | |
Status | Udgivet - jul. 2014 |
Kristmundsson, T., Sonesson, B., Dias, N., Törnqvist, P., Malina, M. & Resch, T., jan. 2014, I: Journal of Vascular Surgery. 59, 1, s. 115-20 6 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Pivot, X., Gligorov, J., Müller, V., Curigliano, G., Knoop, A., Verma, S., Jenkins, V., Scotto, N., Osborne, S., Fallowfield, L. & PrefHer Study Group, okt. 2014, I: Annals of Oncology. 25, 10, s. 1979-1987 9 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Weinberger, D. M., Harboe, Z. B., Viboud, C., Krause, T. G., Miller, M., Mølbak, K. & Konradsen, H. B., mar. 2014, I: European Respiratory Journal. Supplement. 43, 3, s. 833-41 9 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Bank, S., Skytt Andersen, P., Burisch, J., Pedersen, N., Roug, S., Galsgaard, J., Turino, S. Y., Broder Brodersen, J., Rashid, S., Kaiser Rasmussen, B., Avlund, S., Bastholm Olesen, T., Jürgen Hoffmann, H., Kragh Thomsen, M., Ostergaard Thomsen, V., Frydenberg, M., Andersen Nexø, B., Sode, J., Vogel, U. & Andersen, V., 2014, I: P L o S One. 9, 6, s. e98815
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BACKGROUND: The inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative colitis (UC), result from the combined effects of susceptibility genes and environmental factors. Polymorphisms in genes regulating inflammation may explain part of the genetic heritage.
METHODS: Using a candidate gene approach, 39 mainly functional single nucleotide polymorphisms (SNPs) in 26 genes regulating inflammation were assessed in a clinical homogeneous group of severely diseased patients consisting of 624 patients with CD, 411 patients with UC and 795 controls. The results were analysed using logistic regression.
RESULTS: Sixteen polymorphisms in 13 genes involved in regulation of inflammation were associated with risk of CD and/or UC (p≤0.05). The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC. When including all patients (IBD) the polymorphisms TLR2 (rs4696480 and rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs187084), TNFRSF1A (rs4149570), IL6R (rs4537545), IL10 (rs3024505), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk. After Bonferroni correction for multiple testing, both the homozygous and the heterozygous variant genotypes of IL23R G>A(rs11209026) (ORCD,adj: 0.38, 95% CI: 0.21-0.67, p = 0.03; ORIBD,adj 0.43, 95% CI: 0.28-0.67, p = 0.007) and PTPN22 1858 G>A(rs2476601) (ORCD,unadj 0.54, 95% CI: 0.41-0.72, p = 7*10-4; ORIBD,unadj: 0.61, 95% CI: 0.48-0.77, p = 0.001) were associated with reduced risk of CD.
CONCLUSION: The biological effects of the studied polymorphisms suggest that genetically determined high inflammatory response was associated with increased risk of CD. The many SNPs found in TLRs suggest that the host microbial composition or environmental factors in the gut are involved in risk of IBD in genetically susceptible individuals.
Originalsprog | Engelsk |
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Tidsskrift | P L o S One |
Vol/bind | 9 |
Udgave nummer | 6 |
Sider (fra-til) | e98815 |
ISSN | 1932-6203 |
DOI | |
Status | Udgivet - 2014 |
Villadsen, A., Overgaard, S., Holsgaard-Larsen, A., Christensen, R. & Roos, E. M., jun. 2014, I: Annals of the Rheumatic Diseases. 73, 6, s. 1130-7 8 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
OBJECTIVE: To investigate the postoperative efficacy of a supervised programme of neuromuscular exercise prior to hip or knee arthroplasty.
METHODS: In this assessor-blinded randomised controlled trial, we included 165 patients scheduled for hip or knee arthroplasty due to severe osteoarthritis (OA). An 8-week preoperative neuromuscular supervised exercise programme was delivered twice a week for 1 h as adjunct treatment to the standard arthroplasty procedure and compared with the standard arthroplasty procedure alone. The primary outcome was self-reported physical function measured on the activities of daily living (ADL) subscale in the Hip disability and Osteoarthritis Outcome Score (HOOS) and the Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaires for patients with hip and knee OA, respectively. Primary endpoint was 3 months after surgery.
RESULTS: 165 patients randomised to the two groups were on average 67±8 years, 84 (51%) had hip OA and 92 (56%) were women. 153 patients (93%) underwent planned surgery and were evaluated postoperatively. There was no statistically significant difference in effects between hip or knee patients (p=0.7370). Three months postoperatively, no difference was found between groups for ADL (4.4, 95% CI -0.8 to 9.5) or pain (4.5, 95% CI -0.8 to 9.9). However, there was a statistically significant difference indicating an effect of exercise over the entire period (baseline to 3-months postoperatively) (p=0.0029).
CONCLUSIONS: Eight weeks of supervised neuromuscular exercise prior to total joint arthroplasty (TJA) of the hip or knee did not confer additional benefits 3 months postoperatively compared with TJA alone. However, the intervention group experienced a statistically significant short-term benefit in ADL and pain, suggesting an earlier onset of postoperative recovery.
TRIAL REGISTRATION: ClinicalTrials NCT01003756.
Originalsprog | Engelsk |
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Tidsskrift | Annals of the Rheumatic Diseases |
Vol/bind | 73 |
Udgave nummer | 6 |
Sider (fra-til) | 1130-7 |
Antal sider | 8 |
ISSN | 0003-4967 |
DOI | |
Status | Udgivet - jun. 2014 |
Huynh, T. K., Ostergaard, A., Egsmose, C. & Madsen, O. R., 2014, I: Patient Preference and Adherence. 8, s. 93-9 7 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Originalsprog | Engelsk |
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Tidsskrift | Patient Preference and Adherence |
Vol/bind | 8 |
Sider (fra-til) | 93-9 |
Antal sider | 7 |
ISSN | 1177-889X |
DOI | |
Status | Udgivet - 2014 |
Eklund, M. & Morville, A-L., maj 2014, I: Scandinavian Journal of Occupational Therapy. 21, 3, s. 166-71 6 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
AIMS: The Satisfaction with Daily Occupations (SDO) scale assesses satisfaction within the domains of work, leisure, domestic tasks, and self-care. The aim was to investigate the psychometric properties of the Danish version of the SDO when used with asylum seekers.
METHODS: The participants were 93 Danes without known ill health and 43 asylum seekers. They completed the SDO and rated their perceived health, activity level, and general satisfaction with daily occupations. Translation into Danish and back-translation into Swedish was made by professional interpreters.
RESULTS: Internal consistency was α = 0.75 for the Danish sample and α = 0.79 for the asylum seekers. The SDO distinguished between asylum seekers and the Danish sample, suggesting criterion validity. Concurrent validity, analysed against general satisfaction with daily occupations, was indicated for both samples. Discriminant validity was indicated against self-rated health for both samples and against activity level for the Danish sample. There was, however, a correlation of 0.65 between the SDO satisfaction score and activity level for the asylum seekers.
CONCLUSION: The SDO exhibited satisfactory internal consistency and criterion and concurrent validity. The findings regarding discriminant validity were somewhat inconclusive. The Danish SDO may be regarded as psychometrically sound but further psychometric testing is needed.
Originalsprog | Engelsk |
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Tidsskrift | Scandinavian Journal of Occupational Therapy |
Vol/bind | 21 |
Udgave nummer | 3 |
Sider (fra-til) | 166-71 |
Antal sider | 6 |
ISSN | 1103-8128 |
DOI | |
Status | Udgivet - maj 2014 |
Petersen, D. B. & Schmidt, T. A., 2014, I: Journal of Hospital administration. 3, 3, 6 s.
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Schmidt, T. A., mar. 2014, I: Diabetic medicine : a journal of the British Diabetic Association. 31, 3, s. 377-8 2 s.
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