Mackey, A. L., Donnelly, A. E., Swanton, A., Murray, F. & Turpeenniemi-Hujanen, T., aug. 2006, I: Journal of Sports Sciences. 24, 8, s. 843-8 6 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Bredenbruch, F., Geffers, R., Nimtz, M., Buer, J. & Häussler, S., aug. 2006, I: Environmental Microbiology. 8, 8, s. 1318-29 12 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Hölmich, P. & Bachmann Nielsen, M. dec. 2006 I : Ultraschall in der Medizin (Stuttgart, Germany : 1980). 27, 6, s. 509-11 3 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Ultraschall in der Medizin (Stuttgart, Germany : 1980) |
| Vol/bind | 27 |
| Tidsskriftsnummer | 6 |
| Sider (fra-til) | 509-11 |
| Antal sider | 3 |
| ISSN | 0172-4614 |
| DOI | |
| Status | Udgivet - dec. 2006 |
Boesen, M. I., Torp-Pedersen, S., Koenig, M. J., Christensen, R., Langberg, H., Hölmich, P., Nielsen, M. B. & Bliddal, H., sep. 2006, I: British Journal of Sports Medicine. 40, 9, s. 761-6 6 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
BACKGROUND: High resolution colour Doppler ultrasound shows intratendinous Doppler activity in patients with chronic Achilles tendinopathy. Treatment of this neovascularisation with sclerosing therapy seems to relieve the pain. However, the procedure often has to be repeated.
OBJECTIVE: To investigate the effect of electrocoagulation of the neovessels on tendon pain and tendon vascularity in patients with chronic Achilles tendinopathy.
METHODS: Colour Doppler ultrasound guided electrocoagulation was used on vessels in the ventral portion of the Achilles tendon in 11 patients (seven men, four women, mean age 41 years) with painful chronic mid-portion Achilles tendinosis. A unipolar coagulation device was used.
RESULTS: One patient dropped out after two months (dissatisfied with the results). The remaining 10 patients (91%) were satisfied. These 10 patients were still satisfied at six months of follow up and had returned to their previous level of activity. All 10 patients were "cured" after one treatment. The patient who dropped out received two treatments because of lack of progress. There was significantly reduced pain (Likert pain scale, 0-10) during activity, from a median of 7 (range 4 to 10) at baseline to 0 (0 to 8) at six months' follow up (p<0.005); and at rest, from 1.5 (1 to 5) to 0 (0 to 8) (p = 0.005). In all patients, vascularisation was unchanged at the six months follow up, with no significant change in semiquantitative or quantitative colour scoring.
CONCLUSIONS: Coagulation in the area with vessels entering the tendon appears to be effective treatment for painful chronic mid-tendinous Achilles tendinopathy. No effect on the intratendinous Doppler activity could be detected, suggesting that the effect is independent of changes in blood flow. Localisation of hyperaemia appears to be the key to the pathology and for targeting the treatment. One explanation could be that the effect is obtained by destruction of nerves accompanying the vessels.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | British Journal of Sports Medicine |
| Vol/bind | 40 |
| Udgave nummer | 9 |
| Sider (fra-til) | 761-6 |
| Antal sider | 6 |
| ISSN | 0306-3674 |
| DOI | |
| Status | Udgivet - sep. 2006 |
Karsdal, M. A., Henriksen, K., Sørensen, M. G., Gram, J., Schaller, S., Dziegiel, M. H., Heegaard, A-M., Christophersen, P., Martin, T., Christiansen, C. & Bollerslev, J., feb. 2005, I: American Journal of Pathology. 166, 2, s. 467-76 10 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Patients with defective osteoclastic acidification have increased numbers of osteoclasts, with decreased resorption, but bone formation that remains unchanged. We demonstrate that osteoclast survival is increased when acidification is impaired, and that impairment of acidification results in inhibition of bone resorption without inhibition of bone formation. We investigated the role of acidification in human osteoclastic resorption and life span in vitro using inhibitors of chloride channels (NS5818/NS3696), the proton pump (bafilomycin) and cathepsin K. We found that bafilomycin and NS5818 dose dependently inhibited acidification of the osteoclastic resorption compartment and bone resorption. Inhibition of bone resorption by inhibition of acidification, but not cathepsin K inhibition, augmented osteoclast survival, which resulted in a 150 to 300% increase in osteoclasts compared to controls. We investigated the effect of inhibition of osteoclastic acidification in vivo by using the rat ovariectomy model with twice daily oral dosing of NS3696 at 50 mg/kg for 6 weeks. We observed a 60% decrease in resorption (DPYR), increased tartrate-resistant acid phosphatase levels, and no effect on bone formation evaluated by osteocalcin. We speculate that attenuated acidification inhibits dissolution of the inorganic phase of bone and results in an increased number of nonresorbing osteoclasts that are responsible for the coupling to normal bone formation. Thus, we suggest that acidification is essential for normal bone remodeling and that attenuated acidification leads to uncoupling with decreased bone resorption and unaffected bone formation.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | American Journal of Pathology |
| Vol/bind | 166 |
| Udgave nummer | 2 |
| Sider (fra-til) | 467-76 |
| Antal sider | 10 |
| ISSN | 0002-9440 |
| DOI | |
| Status | Udgivet - feb. 2005 |
Størling, J., Allaman-Pillet, N., Karlsen, A. E., Billestrup, N., Bonny, C. & Mandrup-Poulsen, T., apr. 2005, I: Endocrinology. 146, 4, s. 1718-1726 9 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Bredenbruch, F., Nimtz, M., Wray, V., Morr, M., Müller, R. & Häussler, S., jun. 2005, I: Journal of Bacteriology. 187, 11, s. 3630-5 6 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Størling, J., Zaitsev, S. V., Kapelioukh, I. L., Karlsen, A. E., Billestrup, N., Berggren, P. O. & Mandrup-Poulsen, T., jul. 2005, I: Endocrinology. 146, 7, s. 3026-3036 11 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Zwisler, A-D. O., Traeden, U. I., Videbaek, J. & Madsend, M., 2005, I: Scandinavian Journal of Public Health. Supplement. 33, 5, s. 376-83 8 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Zekri, L., Chebli, K., Tourrière, H., Nielsen, F. C., Hansen, T. V. O., Rami, A. & Tazi, J., okt. 2005, I: Molecular and Cellular Biology. 25, 19, s. 8703-16 14 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Cardozo, A. K., Ortis, F., Storling, J., Feng, Y. H., Rasschaert, J., Tonnesen, M., Van Eylen, F., Mandrup-Poulsen, T., Herchuelz, A. & Eizirik, D. L., 1 feb. 2005, I: Diabetes. 54, 2, s. 452-461 10 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Cold, S., Düring, M., Ewertz, M., Knoop, A. & Møller, S., 19 sep. 2005, I: British Journal of Cancer. 93, 6, s. 627-32 6 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Masmas, T. N., Madsen, H. O., Petersen, S. L., Ryder, L. P., Svejgaard, A., Alizadeh, M. & Vindeløv, L. L., jul. 2005, I: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 11, 7, s. 558-66 9 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Petersen, J. & Hölmich, P. jun. 2005 I : British Journal of Sports Medicine. 39, 6, s. 319-23 5 s.
Publikation: Bidrag til tidsskrift › Review › Forskning › peer review
A common soft tissue injury in sports involving sprinting and jumping is the hamstring strain. A major problem with hamstring strains is the high incidence of reinjury. Muscle injuries can be classified as direct or indirect and are typically grouped into three categories according to severity. A number of potential risk factors have been proposed for hamstring strains. Only a few are evidence based and some are mainly based on theoretical assumptions. There is a lack of clinical research on the effectiveness of rehabilitation programmes for hamstring strains. Although the initial treatment of rest, ice, compression, and elevation is accepted for muscle strains, no consensus exists for their rehabilitation. Not much evidence based research has been carried out on prevention of hamstring strain. To our knowledge only two prospective studies have so far been published. As the injuries are common in football and other sports involving sprinting and jumping, there is a need for further research preferably in the form of randomised controlled trials.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | British Journal of Sports Medicine |
| Vol/bind | 39 |
| Tidsskriftsnummer | 6 |
| Sider (fra-til) | 319-23 |
| Antal sider | 5 |
| ISSN | 0306-3674 |
| DOI | |
| Status | Udgivet - jun. 2005 |
Tønnesen, H., Fugleholm, A. M. & Jørgensen, S. J., 2005, Health promotion in hospitals: Evidence and quality management. Copenhagen: WHO Regional Office for Europe
Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › peer review
| Originalsprog | Engelsk |
|---|---|
| Titel | Health promotion in hospitals: Evidence and quality management |
| Udgivelsessted | Copenhagen |
| Forlag | WHO Regional Office for Europe |
| Publikationsdato | 2005 |
| Status | Udgivet - 2005 |
Kollgaard, T., Petersen, S. L., Hadrup, S. R., Masmas, T. N., Seremet, T., Andersen, M. H., Madsen, H. O., Vindeløv, L. & thor Straten, P., dec. 2005, I: Leukemia. 19, 12, s. 2273-80 8 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Hammer, N. A., Hansen, T. V. O., Byskov, A. G., Rajpert-De Meyts, E., Grøndahl, M. L., Bredkjaer, H. E., Wewer, U. M., Christiansen, J. & Nielsen, F. C., aug. 2005, I: Reproduction (Cambridge, England). 130, 2, s. 203-12 10 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Larsen, L., Størling, J., Darville, M., Eizirik, D. L., Bonny, C., Billestrup, N. & Mandrup-Poulsen, T., dec. 2005, I: Diabetologia. 48, 12, s. 2582-2590 9 s.
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Goldstein, H. & Tønnesen, H., 7 mar. 2005, I: Ugeskrift for Laeger. 167, 10, s. 1177-80 4 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning
| Bidragets oversatte titel | [Preventive medicine in Danish hospitals] |
|---|---|
| Originalsprog | Dansk |
| Tidsskrift | Ugeskrift for Laeger |
| Vol/bind | 167 |
| Udgave nummer | 10 |
| Sider (fra-til) | 1177-80 |
| Antal sider | 4 |
| ISSN | 0041-5782 |
| Status | Udgivet - 7 mar. 2005 |
Rasmussen, S., Zwisler, A-D. O., Abildstrom, S. Z., Madsen, J. K. & Madsen, M., okt. 2005, I: Medical Care. 43, 10, s. 970-8 9 s.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review