Published in 2006

Favourable effect of TNF-alpha inhibitor (infliximab) on Blau syndrome in monozygotic twins with a de novo CARD15 mutation

Milman, N., Andersen, C. B., Hansen, A., van Overeem Hansen, T., Nielsen, F. C., Fledelius, H., Ahrens, P. & Nielsen, O. H., dec. 2006, I: APMIS - Journal of Pathology, Microbiology and Immunology. 114, 12, s. 912-9 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Identification of Burkholderia cepacia complex pathogens by rapid-cycle PCR with fluorescent hybridization probes

Vonberg, R-P., Häußler, S., Vandamme, P. & Steinmetz, I., jun. 2006, I: Journal of Medical Microbiology. 55, Pt 6, s. 721-727 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

IL-1β-induced pro-apoptotic signalling is facilitated by NCAM/FGF receptor signalling and inhibited by the C3d ligand in the INS-1E rat beta cell line

Petersen, L. G., Størling, J., Heding, P., Li, S., Berezin, V., Saldeen, J., Billestrup, N., Bock, E. & Mandrup-Poulsen, T., aug. 2006, I: Diabetologia. 49, 8, s. 1864-1875 12 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Impulse-forces during walking are not increased in patients with knee osteoarthritis

Henriksen, M., Simonsen, E. B., Graven-Nielsen, T., Lund, H., Danneskiold-Samsøe, B. & Bliddal, H., aug. 2006, I: Acta Orthopaedica . 77, 4, s. 650-6 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

BACKGROUND: Impulsive forces in the knee joint have been suspected to be a co-factor in the development and progression of knee osteoarthritis. We thus evaluated the impulsive sagittal ground reaction forces (iGRF), shock waves and lower extremity joint kinematics at heel strike during walking in knee osteoarthritis (OA) patients and compared them to those in healthy subjects.

SUBJECTS AND METHODS: We studied 9 OA patients and 10 healthy subjects using three-dimensional gait analyses concentrated on the heel strike. Impulse GRF (iGRF) was measured together with peak accelerations (PA) at the tibial tuberosity and sacrum. Sagittal lower extremity joint angles at heel strike were extracted from the gait analyses. As OA is painful and pain might alter movement strategies, the patient group was also evaluated following pain relief by intraarticular lidocaine injections.

RESULTS: The two groups showed similar iGRF, similar tibial and sacral PA, and similar joint angles at heel strike. Following pain relief, the OA patients struck the ground with more extended hip and knee joints and lower tibial PA compared to the painful condition. Although such changes occurred after pain relief, all parameters were within their normal ranges.

INTERPRETATION: OA patients and healthy subjects show similar impulse-forces and joint kinematics at heel strike. Following pain relief in the patient group, changes in tibial PA and in hip and knee joint angles were observed but these were still within the normal range. Our findings make us question the hypothesis that impulse-forces generated at heel strike during walking contribute to progression of OA.

Originalsprog Engelsk
Tidsskrift Acta Orthopaedica
Vol/bind 77
Udgave nummer 4
Sider (fra-til) 650-6
Antal sider 7
ISSN 1745-3674
DOI
Status Udgivet - aug. 2006

Increased joint loads during walking--a consequence of pain relief in knee osteoarthritis

Henriksen, M., Simonsen, E. B., Alkjaer, T., Lund, H., Graven-Nielsen, T., Danneskiold-Samsøe, B. & Bliddal, H., dec. 2006, I: The Knee. 13, 6, s. 445-50 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Joint pain is a primary symptom in knee osteoarthritis (OA), but the effect of pain and pain relief on the knee joint mechanics of walking is not clear. In this study, the effects of local knee joint analgesia on knee joint loads during walking were studied in a group of knee osteoarthritis patients. A group of healthy subjects was included as a reference group. The joint loads were calculated from standard gait analysis data obtained with standardised walking speed (4 km/h). The gait analyses were performed before and after pain relief by intra-articular injections of 10 mL lidocaine (1%). Pre-injection measurements revealed lower joint loads in the OA group compared to the reference group. Following injections pain during walking decreased significantly and the joint loads increased in the OA group during the late single support phase to a level comparable to the reference group. Although the patients walked with less compressive knee joint forces compared to the reference group, the effects of pain relief may accelerate the degenerative changes.

Originalsprog Engelsk
Tidsskrift The Knee
Vol/bind 13
Udgave nummer 6
Sider (fra-til) 445-50
Antal sider 6
ISSN 0968-0160
DOI
Status Udgivet - dec. 2006

Inflammation and miscarriage

Christiansen, O. B., Nielsen, H. S. & Kolte, A. M., okt. 2006, I: Seminars in Fetal & Neonatal Medicine. 11, 5, s. 302-8 7 s.

Publikation: Bidrag til tidsskriftReviewpeer review

Inherited hemoglobin disorders in Guinea-Bissau, West Africa: a population study

Masmas, T. N., Garly, M-L., Lisse, I. M., Rodriques, A., Petersen, P. T. & Birgens, H., 2006, I: Hemoglobin. 30, 3, s. 355-64 10 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Long-term recurrence and death rates after acute pancreatitis

Lund, H., Tønnesen, H., Tønnesen, M. H. & Olsen, O., 1 feb. 2006, I: Scandinavian Journal of Gastroenterology. 41, 2, s. 234-8 5 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

The aim of this study was to compare long-term recurrence and death rates after a first episode of acute pancreatitis in patients with and without gallstones. Additionally, it was of interest to find out if there were factors predictive of readmission or death.
Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Gastroenterology
Vol/bind 41
Udgave nummer 2
Sider (fra-til) 234-8
Antal sider 5
ISSN 0036-5521
DOI
Status Udgivet - 1 feb. 2006

Lægens rolle i rehabilitering

Tønnesen, H., Bendix, A. F. & Hendriksen, C., 2006, København: Laegeforeningens Forlag.

Publikation: Bog/antologi/afhandling/rapportBogForskning

Originalsprog Dansk
Udgivelsessted København
Forlag Laegeforeningens Forlag
Status Udgivet - 2006

Quorum-sensing antagonistic activities of azithromycin in Pseudomonas aeruginosa PAO1: a global approach

Nalca, Y., Jänsch, L., Bredenbruch, F., Geffers, R., Buer, J. & Häussler, S., maj 2006, I: Antimicrobial Agents and Chemotherapy. 50, 5, s. 1680-8 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Reproducibility of ultrasound and magnetic resonance imaging measurements of tendon size

Brushøj, C., Henriksen, B. M., Albrecht-Beste, E., Hölmich, P., Larsen, K. & Bachmann Nielsen, M. nov. 2006 I : Acta Radiologica. 47, 9, s. 954-9 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

PURPOSE: To investigate the intra- and inter-tester reproducibility of measurements of the Achilles tendon, tibialis anterior tendon, and the tibialis posterior tendon in football players using ultrasound (US) and magnetic resonance imaging (MRI).

MATERIAL AND METHODS: Eleven asymptomatic football players were examined. Using a standardized US scanning protocol, the tendons were examined by two observers with US for thickness, width, and cross-sectional area. One observer conducted the procedure twice. The subjects also underwent an MRI examination, and the assessment of tendon size was conducted twice by two observers.

RESULTS: The best reproducibility judged by coefficient of variation (CV) and 95% confidence interval was determined for the Achilles tendon on both US and MRI. The variability of US on measurements on the tibialis anterior and tibialis posterior tendons was less than that when using MRI. In 12 out of 18 measurements, there were systematic differences between observers as judged by one-sided F-test.

CONCLUSION: The reproducibility of the three tendons was limited. Precaution should be taken when looking for minor quantitative changes, i.e., training-induced hypertrophy, and when doing so, the Achilles tendon should be used.

Originalsprog Engelsk
Tidsskrift Acta Radiologica
Vol/bind 47
Tidsskriftsnummer 9
Sider (fra-til) 954-9
Antal sider 6
ISSN 0284-1851
DOI
Status Udgivet - nov. 2006

RhlR expression in Pseudomonas aeruginosa is modulated by the Pseudomonas quinolone signal via PhoB-dependent and -independent pathways

Jensen, V., Löns, D., Zaoui, C., Bredenbruch, F., Meissner, A., Dieterich, G., Münch, R. & Häussler, S., dec. 2006, I: Journal of Bacteriology. 188, 24, s. 8601-6 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Risk reduction: perioperative smoking intervention

Møller, A. & Tønnesen, H., 1 jun. 2006, I: Best Practice & Research: Clinical Anaesthesiology. 20, 2, s. 237-48 12 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

Smoking is a well-known risk factor for perioperative complications. Smokers experience an increased incidence of respiratory complications during anaesthesia and an increased risk of postoperative cardiopulmonary complications, infections and impaired wound healing. Smokers have a greater risk of postoperative intensive care admission. Even passive smoking is associated with increased risk at operation. Preoperative smoking intervention 6-8 weeks before surgery can reduce the complications risk significantly. Four weeks of abstinence from smoking seems to improve wound healing. An intensive, individual approach to smoking intervention results in a significantly better postoperative outcome. Future research should focus upon the effect of a shorter period of preoperative smoking cessation. All smokers admitted for surgery should be informed of the increased risk, recommended preoperative smoking cessation, and offered a smoking intervention programme whenever possible.
Originalsprog Engelsk
Tidsskrift Best Practice & Research: Clinical Anaesthesiology
Vol/bind 20
Udgave nummer 2
Sider (fra-til) 237-48
Antal sider 12
ISSN 1753-3740
Status Udgivet - 1 jun. 2006

RNA-binding IMPs promote cell adhesion and invadopodia formation

Vikesaa, J., Hansen, T. V. O., Jønson, L., Borup, R., Wewer, U. M., Christiansen, J. & Nielsen, F. C., 5 apr. 2006, I: The EMBO Journal. 25, 7, s. 1456-68 13 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Role of PDE5 in migraine

Kruuse, C., 5 dec. 2006, Cyclic Nucleotide Phosphodiesterases in Health and Disease. CRC Press, s. 519-537 19 s.

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskningpeer review

RX871024 reduces NO production but does not protect against pancreatic β-cell death induced by proinflammatory cytokines

Zaitseva, I. I., Sharoyko, V., Størling, J., Efendic, S., Guerin, C., Mandrup-Poulsen, T., Nicotera, P., Berggren, P. O. & Zaitsev, S. V., 8 sep. 2006, I: Biochemical and Biophysical Research Communications. 347, 4, s. 1121-1128 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Short-term lower leg growth in asthmatic children treated with inhaled beta2-agonists.

Plomgaard, A. M., mar. 2006, I: Annals of Human Biology. 33 (2), s. 135-41 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The effect of a therapeutic dendritic cell-based cancer vaccination depends on the blockage of CTLA-4 signaling

Met, Ö., Wang, M., Pedersen, A. E., Nissen, M. H., Buus, S. & Claesson, M. H., 18 jan. 2006, I: Cancer Letters. 231, 2, s. 247-256 10 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The effect of computerized tailored brief advice on at-risk drinking in subcritically injured trauma patients

Neumann, T., Neuner, B., Weiss-Gerlach, E., Tønnesen, H., Gentilello, L. M., Wernecke, K-D., Schmidt, K., Schröder, T., Wauer, H., Heinz, A., Mann, K., Müller, J. M., Haas, N., Kox, W. J. & Spies, C. D., 1 okt. 2006, I: Journal of Trauma. 61, 4, s. 805-14 10 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

One-third of injured patients treated in the emergency department (ED) have an alcohol use disorder (AUD). Few are screened and receive counseling because ED staff have little time for additional tasks. We hypothesized that computer technology can screen and provide an intervention that reduces at-risk drinking (British Medical Association criteria) in injured ED patients.
Originalsprog Engelsk
Tidsskrift Journal of Trauma
Vol/bind 61
Udgave nummer 4
Sider (fra-til) 805-14
Antal sider 10
ISSN 0022-5282
DOI
Status Udgivet - 1 okt. 2006

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