Published in 2018

Carotid intima-media thickness (IMT) and ankle brachial index (ABI) are non-invasive indicators of generalised atherosclerosis. The aim was to determine the association between carotid IMT and ABI in subjects with and without diabetes mellitus (DM), and to analyse specific age change-points. We included 2744 subjects from the Copenhagen City Heart Study (mean age (SD) 56.6 (17.2) years, 56.8% women and body mass index (BMI) 25.4 (4.1) kg/m2). Carotid IMT and ABI measurements were performed during the fifth examination. Of the 2744 subjects, 125 subjects (4.6%) had DM. Average carotid IMT was 0.667 (0.145) mm and ABI was 1.06 (0.14). Subjects with DM were older, had higher BMI and systolic blood pressure (SBP) (all p < .001). Carotid IMT was higher in subjects with DM (0.754 (0.150) mm) compared to subjects without DM (0.662 (0.144) mm) (p < .001), whereas there was no difference in ABI between the two groups. ABI was inversely associated with carotid IMT (slope = -0.17 [-0.207; -0.137] (p < .001). The association remained significant after adjustment for risk factors both in subjects with DM (slope = -0.168 [-0.328; -0.007], p = .040), and in subjects without DM (slope = -0.100 [-0.148; -0.052], p < .001), with a stronger effect of carotid IMT on ABI among subjects with DM. Carotid IMT and ABI were inversely associated in subjects with DM and without DM, but with a stronger effect in subjects with DM. Age and ABI revealed a change-point with a stronger inverse association among subjects aged >60 years.

Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Clinical and Laboratory Investigation
Vol/bind 78
Udgave nummer 6
Sider (fra-til) 464-469
Antal sider 6
ISSN 0036-5513
DOI
Status Udgivet - 2018
Originalsprog Engelsk
Artikelnummer SAT0081
Tidsskrift Annals of the Rheumatic Diseases
Vol/bind 77
Udgave nummer Suppl. 2
Sider (fra-til) 903
Antal sider 1
ISSN 0003-4967
Status Udgivet - 2018

Changes in job strain and subsequent weight gain: a longitudinal study, based on the Danish Nurse Cohort

Vesterlund, G. K., Keller, A. C. & Heitmann, B. L., apr. 2018, I : Public Health Nutrition. 21, 6, s. 1131-1138 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

OBJECTIVE: Obesity as well as job strain is increasing, and job strain might contribute to weight gain. The objective of the current study was to examine associations between longitudinal alterations in the components of job strain and subsequent weight gain.

DESIGN: The study was designed as a prospective cohort study with three questionnaire surveys enabling measurement of job-strain alterations over 6 years and subsequent measurements of weight gain after further 10 years of follow-up. ANCOVA and trend analyses were conducted. Job demands were measured as job busyness and speed, and control as amount of influence.

SETTING: Employed nurses in Denmark.

SUBJECTS: We included a sub-sample of 6188 female nurses from the Danish Nurse Cohort, which consisted of the nurses who participated in surveys in 1993, 1999 and 2009.

RESULTS: A linear trend in weight gain was seen in nurses who were often busy in 1999 between those who were rarely v. sometimes v. often busy in 1993 (P=0·03), with the largest weight gain in individuals with sustained high busyness in both years. Loss of influence between 1993 and 1999 was associated with larger subsequent weight gain than sustained high influence (P=0·003) or sustained low influence (P=0·02). For speed, no associations were found.

CONCLUSIONS: Busyness, speed and influence differed in their relationship to subsequent weight gain. A decrease in job influence and a sustained burden of busyness were most strongly related to subsequent weight gain. Focus on job strain reduction and healthy diet is essential for public health.

Originalsprog Engelsk
Tidsskrift Public Health Nutrition
Vol/bind 21
Udgave nummer 6
Sider (fra-til) 1131-1138
Antal sider 8
ISSN 1368-9800
DOI
Status Udgivet - apr. 2018

Comparative effectiveness and prognostic factors for outcome of surgical and non-surgical management of lumbar spinal stenosis in an elderly population: protocol for an observational study

Brøgger, H. A., Maribo, T., Christensen, R. & Schiøttz-Christensen, B., 19 dec. 2018, I : BMJ Open. 8, 12, s. e024949

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

INTRODUCTION: Lumbar spinal stenosis is a common cause of low back and leg pain in the elderly and affects both physical activity and quality of life. First-line treatments are non-surgical options but if unsuccessful, surgery is advocated. The literature is not clear as to the outcome of surgery compared with non-surgical treatment, and the optimal time for surgery is not explicit. This observational study is designed to investigate the course of treatment, compare effectiveness of surgical and non-surgical management in patients with lumbar spinal stenosis and identify prognostic factors for outcome in the context of current clinical practice.

MATERIALS AND ANALYSIS: Prospectively registered data on treatment, outcome and patient characteristics are collected from nationwide registers on health and social issues, a clinical registry of people with chronic back pain and hospital medical records. Primary outcome is change in physical function measured by the Zurich Claudication Questionnaire. Secondary outcomes are changes in symptom severity, pain-related function, health-related quality of life and general self-efficacy. Outcomes are assessed at baseline and 6 and 12 months. Outcomes at 12 months will be compared for patients who undergo surgery for lumbar spinal stenosis and patients managed non-surgically, using different analytical approaches. Prespecified prognostic factors of interest at baseline include treatment allocation, back and leg pain intensity, comorbidity, duration of symptoms, pretreatment function, self-rated health, income, general self-efficacy and MRI-graded severity of central stenosis.

ETHICS AND DISSEMINATION: The study has been evaluated by the Regional Committees on Health Research for Southern Denmark (S-20172000-200) and notified to the Danish Data Protection Agency (18/22336). All participants provide consent. Findings will be disseminated in peer-reviewed publications and presented at national and international conferences according to the Strengthening the Reporting of Observational Studies in Epidemiology and Prognosis Research Strategy statements. Potential sources of bias will be addressed using Risk of Bias in Non-randomised Studies of Interventions.

TRIAL REGISTRATION NUMBER: NCT03548441; Pre-results.

Originalsprog Engelsk
Tidsskrift BMJ Open
Vol/bind 8
Udgave nummer 12
Sider (fra-til) e024949
ISSN 2044-6055
DOI
Status Udgivet - 19 dec. 2018

COMPOSITIONAL MAGNETIC RESONANCE IMAGING OF CARTILAGE AND MENISCI IN KNEE OSTEOARTHRITIS

Hangaard, S., 30 maj 2018, 66 s.

Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandlingForskning

Originalsprog Engelsk
Antal sider 66
Status Udgivet - 30 maj 2018

Concentration of 25-hydroxyvitamin D from neonatal dried blood spots and the relation to gestational age, birth weight and Ponderal Index: the D-tect study

Keller, A., Händel, M. N., Frederiksen, P., Jacobsen, R., Cohen, A. S., McGrath, J. J. & Heitmann, B. L., jun. 2018, I : The British journal of nutrition. 119, 12, s. 1416-1423 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Studies have suggested that vitamin D status at birth may be associated with a range of neonatal outcomes. The aim of this study was to assess the association between neonatal 25-hydroxyvitamin D3 (25(OH)D3) concentration and gestational age, birth weight, Ponderal Index and size for gestational age. Neonatal capillary blood stored as dried blood spots was used to assess 25(OH)D3 concentrations among 2686 subjects selected from a random population sub-sample of individuals, born in Denmark from 1 May 1981 to 31 December 2002. There was an inverse association between 25(OH)D3 concentration and gestational age at birth of -0·006 (95 % CI -0·009, -0·003, P<0·001) weeks of gestation per 1 nmol/l increase in 25(OH)D3 concentration. An inverted U-shaped association between 25(OH)D3 and birth weight and Ponderal Index (P=0·04) was found, but no association with size for gestational age was shown. This study suggests that neonatal 25(OH)D3 concentration is associated with anthropometric measures at birth known to be correlated with many subsequent health outcomes such as obesity and type 2 diabetes.

Originalsprog Engelsk
Tidsskrift The British journal of nutrition
Vol/bind 119
Udgave nummer 12
Sider (fra-til) 1416-1423
Antal sider 8
ISSN 0007-1145
DOI
Status Udgivet - jun. 2018

Confirmation of an IRAK3 polymorphism as a genetic marker predicting response to anti-TNF treatment in rheumatoid arthritis

Sode, J., Vogel, U., Bank, S., Andersen, P. S., Hetland, M. L., Locht, H., Heegaard, N. H. H. & Andersen, V. 2018 I : The pharmacogenomics journal.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Several genetic variants in Toll-like receptor (TLR) and nuclear factor (NF)-κB signalling pathways have been reported associated with responsiveness to tumour necrosis factor inhibitor (anti-TNF) treatment in rheumatoid arthritis (RA). The present study was undertaken to replicate these findings. In a retrospective case-case study including 1007 Danish anti-TNF-treated RA patients, we genotyped 7 previously reported associated single-nucleotide polymorphisms (SNPs) in these pathways. Furthermore, 5 SNPs previously reported by our group were genotyped in a subcohort (N=469). Primary analyses validated the IRAK3 rs11541076 variant as associated (odds ratio (OR)=1.33, 95% confidence interval (CI): 1.00-1.77, P-value=0.047) with a positive treatment response (EULAR (European League Against Rheumatism) good/moderate vs none response at 4±2 months), and found the NLRP3 rs461266 variant associated (OR=0.75, 95% CI: 0.60-0.94, P=0.014) with a negative treatment response. Meta-analyses combining data from previous studies suggested smaller effect sizes of associations between variant alleles of CHUK rs11591741, NFKBIB rs3136645 and rs9403 and a negative treatment response. In conclusion, this study validates rs11541076 in IRAK3, a negative regulator of TLR signalling, as a predictor of anti-TNF treatment response, and suggests true positive associations of previously reported SNPs within genes encoding activators/inhibitors of NF-κB (CHUK, MYD88, NFKBIB, and NLRP3).The Pharmacogenomics Journal advance online publication, 4 October 2016; doi:10.1038/tpj.2016.66.

Originalsprog Engelsk
Tidsskrift The pharmacogenomics journal
ISSN 1470-269X
DOI
Status E-pub ahead of print - 2018

Correction to: Recommendations for the management of rheumatoid arthritis in the Eastern Mediterranean region: an adolopment of the 2015 American College of Rheumatology guidelines

Arayssi, T., Harfouche, M., Darzi, A., Al Emadi, S., Alnaqbi, K. A., Badsha, H., Al Balushi, F., Dib, C., Elzorkany, B., Halabi, H., Hammoudeh, M., Hazer, W., Masri, B., Merashli, M., Omair, M., Salloum, N., Uthman, I., Zahirovic, S., Ziade, N., Bannuru, R. R., McAlindon, T., Nomier, M. A., Singh, J. A., Christensen, R., Tugwell, P., Schünemann, H. & Akl, E. A., nov. 2018, I : Clinical Rheumatology. 37, 11, s. 2961-2962 2 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

In the original version of this article the first name of the co-author was incorrectly spelled as "Khaled A. Alnaqbi". The correct spelling should have been "Khalid A. Alnaqbi". This is now presented correctly in this article.

Originalsprog Engelsk
Tidsskrift Clinical Rheumatology
Vol/bind 37
Udgave nummer 11
Sider (fra-til) 2961-2962
Antal sider 2
ISSN 0770-3198
DOI
Status Udgivet - nov. 2018

Correction: Opportunities and challenges for real-world studies on chronic inflammatory joint diseases through data enrichment and collaboration between national registers: the Nordic example

Chatzidionysiou, K., Hetland, M. L., Frisell, T., Giuseppe, D. D., Hellgren, K., Glintborg, B., Nordström, D., Aaltonen, K., Törmänen, M. R. K., Kristianslund, E. K., Kvien, T. K., Provan, S. A., Gudbjörnsson, B., Dreyer, L., Kristensen, L. E., Jørgensen, T. S., Jacobsson, L. & Askling, J., 2018

Publikation: AndetAndet bidragForskning

[This corrects the article DOI: 10.1136/rmdopen-2018-000655.].

Originalsprog Engelsk
Publikationsdato 2018
Udgave 1
Vol/bind 4
DOI
Status Udgivet - 2018
Navn RMD Open
ISSN 2056-5933

Cross-sectional associations between maternal self-efficacy and dietary intake and physical activity in four-year-old children of first-time Swedish mothers

Rohde, J. F., Bohman, B., Berglind, D., Hansson, L. M., Frederiksen, P., Mortensen, E. L., Heitmann, B. L. & Rasmussen, F., 1 jun. 2018, I : Appetite. 125, s. 131-138 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

BACKGROUND: Healthy dietary and physical activity behaviours are established early in life where children learn by observing their parents. Therefore, parents can act as role models and influence their children toward a healthier lifestyle. Besides a strong association between parental and child health behaviours, parents also influence their children's health behaviours through socio-cognitive processes, where perceived self-efficacy is the central component. The objective was to examine if parental self-efficacy among Swedish mothers was associated with their four-year-old children's dietary and physical activity behaviours.

METHODS: This cross-sectional study was based on information from control participants that took part in the Swedish primary prevention trial of childhood obesity (PRIMROSE) (n = 420 mother-child pairs). Linear regression models were used to examine the associations between parental self-efficacy (Parental Self-Efficacy for Promoting Healthy Physical Activity and Dietary Behaviours in Children Scale) and children's dietary intake (parent reported) and levels of physical activity (accelerometer) with adjustments for potential confounders.

RESULTS: Mothers' efficacy beliefs in promoting healthy dietary or physical activity behaviours in their children were associated with a slightly higher consumption of fruit and vegetables among their children (β: 0.03 [95%CI: 0.01; 0.04] P < 0.001) and slightly higher levels of moderate-to-vigorous activity (β: 0.43 [95%CI: 0.05; 0.81] P = 0.03). Mothers' belief in their ability to limit unhealthy dietary and physical activity behaviours was inversely associated with children's intake of unhealthy snacks (β: -0.06 [95%CI: -0.10; -0.02] P < 0.01).

CONCLUSION: Our cross-sectional study suggests weak positive correlations between maternal self-efficacy and healthy dietary and physical activity behaviours, and weak inverse associations between maternal self-efficacy and unhealthy dietary and physical activity behaviours among their children.

Originalsprog Engelsk
Tidsskrift Appetite
Vol/bind 125
Sider (fra-til) 131-138
Antal sider 8
ISSN 0195-6663
DOI
Status Udgivet - 1 jun. 2018

Day-to-Day Reliability of Nonlinear Methods to Assess Walking Dynamics

Raffalt, P. C., Alkjær, T., Brynjólfsson, B., Jørgensen, L., Bartholdy, C. & Henriksen, M., 1 dec. 2018, I : Journal of Biomechanics. 140, 12

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The present study investigated the day-to-day reliability (quantified by the absolute and relative reliability) of nonlinear methods used to assess human locomotion dynamics. Twenty-four participants of whom twelve were diagnosed with knee osteoarthritis completed 5 min of treadmill walking at self-selected preferred speed on two separate days. Lower limb kinematics were recorded at 100 Hz and hip, knee, and ankle joint angles, three-dimensional (3D) sacrum marker displacement and stride time intervals were extracted for 170 consecutive strides. The largest Lyapunov exponent and correlation dimension were calculated for the joint angle and sacrum displacement data using three different state space reconstruction methods (group average, test-retest average, individual time delay and embedding dimension). Sample entropy and detrended fluctuation analysis (DFA) were applied to the stride time interval time series. Relative reliability was assessed using intraclass correlation coefficients and absolute reliability was determined using measurement error (ME). For both joint angles and sacrum displacement, there was a general pattern that the group average state space reconstruction method provided the highest relative reliability and lowest ME compared to the individual and test-retest average methods. The DFA exhibited good reliability, while the sample entropy showed poor reliability. The results comprise a reference material that can inspire and guide future studies of nonlinear gait dynamics.

Originalsprog Engelsk
Tidsskrift Journal of Biomechanics
Vol/bind 140
Udgave nummer 12
ISSN 0021-9290
DOI
Status Udgivet - 1 dec. 2018

BACKGROUND: Early cartilage changes in knee osteoarthritis (OA) can be assessed by both intravenous (i.v.) and intra-articular (i.a.) delayed gadolinium-enhanced MRI of cartilage (dGEMRIC).

PURPOSE: To examine the relationship between i.a. dGEMRIC and delayed gadolinium-enhanced MRI of menisci (dGEMRIM), and to investigate if the approach can be used to assess the morphological degeneration of menisci in obese patients with knee OA.

STUDY TYPE: Cross-sectional.

POPULATION: Eighty-five obese patients with knee OA.

FIELD STRENGTH/SEQUENCES: 1.5T. Inversion recovery sequence with four inversion times.

ASSESSMENT: T1 relaxation times were calculated for posterior weight-bearing femoral cartilage and the posterior horns of the menisci. Meniscus degeneration sum score (0-2) was assessed as increased signal/no signal (1/0) and tear/no tear (1/0).

STATISTICAL TESTS: T1 relaxation times were compared using Student's t-test. Comparison of cartilage and meniscus T1 relaxation times was done by regression analysis. Analysis of variance (ANOVA) was used for comparison of meniscal T1 relaxation times among the three summed morphological scores (0-2). Statistical analyses were performed with a level of significance at 0.05.

RESULTS: For lateral menisci, morphology sum scores of 0, 1, and 2 were found in 13, 58, and 14 patients and for medial menisci in 2, 30, and 30 patients, respectively. Mean T1 relaxation times were 441 msec, 480 msec, and 497 msec for cartilage, lateral menisci, and medial menisci, respectively. T1 relaxation times for the menisci were similar (P = 0.53), and a weak correlation was found between dGEMRIC and dGEMRIM in the lateral compartments (R = 0.26). Comparing dGEMRIM between different morphology sum scores showed no differences (P > 0.4).

DATA CONCLUSION: I.a. dGEMRIM showed no correlation between the degree of meniscal degeneration and meniscus T1 relaxation times. I.a. dGEMRIM do not seem to deliver useful information about meniscus degeneration to be suitable for clinical applications, but i.a. dGEMRIC may still be considered an alternative contrast-saving method for cartilage.

LEVEL OF EVIDENCE: 3 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2018;48:1700-1706.

Originalsprog Engelsk
Tidsskrift Journal of magnetic resonance imaging : JMRI
Vol/bind 48
Udgave nummer 6
Sider (fra-til) 1700-1706
Antal sider 7
ISSN 1053-1807
DOI
Status Udgivet - dec. 2018
Originalsprog Engelsk
Udgivelses sted [Kbh.]
Forlag University of Copenhagen, Faculty of Health and Medical Sciences
Antal sider 270
Status Udgivet - 2018

Disease Modifying Therapies in Psoriatic Arthritis: Prognostic Factors and Treatment Outcomes

Højgaard, P., 28 feb. 2018, Eget forlag, København. 78 s.

Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandlingForskning

Originalsprog Engelsk
Forlag Eget forlag, København
Antal sider 78
Status Udgivet - 28 feb. 2018

Diverse hepatic microbial DNA fingerprints in healthy lean and obese steatotic humans

Bagger, J. I., Suppli, M. P., Nielsen, T., Lelouvier, B., Broha, A., Demant, M. G., Kønig, M. J., Strandberg, C., Lund, A., Vilsbøll, T. & Knop, F. K. 2 okt. 2018 (Accepteret/In press)

Publikation: KonferencebidragKonferenceabstrakt til konferenceForskningpeer review

Originalsprog Engelsk
Publikationsdato 2 okt. 2018
Status Accepteret/In press - 2 okt. 2018
Begivenhed 54th EASD Annual Meeting: EASD 2018 - Berlin, Tyskland
Varighed: 1 okt. 20185 okt. 2018
https://www.easd.org/programme-2018.html

Konference

Konference 54th EASD Annual Meeting
Land Tyskland
By Berlin
Periode 01/10/201805/10/2018
Internetadresse

Dose tapering and discontinuation of biological therapy in rheumatoid arthritis patients in remission in routine care – 2-year outcomes and identification of predictors

Brahe, C. C. H., Krabbe, S., Østergaard, M., Ørnbjerg, L. M., Glinatsi, D. E., Røgind, H., Jensen, H. S., Hansen, A., Nørregaard, J., Jacobsen, S., Terslev, L., Huynh, T. K., Jensen, D. V., Manilo, N., Asmussen, K., Frandsen, P. B., Boesen, M., Rastiemadabadi, Z., Morsel-Carlsen, L., Møller, J. M., Krogh, N. S. & Hetland, M. L., 2018, I : Annals of the Rheumatic Diseases. 77, Suppl. 2, s. 70-1 2 s., OP0038.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

Originalsprog Engelsk
Artikelnummer OP0038
Tidsskrift Annals of the Rheumatic Diseases
Vol/bind 77
Udgave nummer Suppl. 2
Sider (fra-til) 70-1
Antal sider 2
ISSN 0003-4967
Status Udgivet - 2018

Infants who are breastfed are introduced to a variety of flavours from the maternal milk, and thus the transition from maternal milk to complementary foods may be easier for these children. The aim of this study was to investigate if duration of exclusive breastfeeding was associated with pickiness or dietary intake of vegetables, fruit, starchy foods or sugar sweetened beverages among obesity prone normal weight children aged 2-6 years. This cohort study was based on data from the Healthy Start primary intervention study, the Danish Medical Birth registry and the Danish Health Visitor's Child Health Database. Infant feeding was registered by health nurses while home-visiting the mother and child up to four times within the first year. Information on eating behaviour and diet intake at age 2-6 years was obtained by parents. Crude and adjusted logistic and general linear regression models were used to investigate associations. A total of 236 children had complete information on all variables. Data showed lower odds of picky eating behaviour when exclusively breastfed until age 4-5 months compared to exclusively breastfed for 0-1 months (OR = 0.35, 95CI = 0.16;0.76, p = 0.008). In the crude analysis only, exclusively breastfed until age 6-10 months was associated with a higher daily intake of vegetables (p = 0.04). This study suggests that exclusive breastfeeding duration seems to influence pickiness and may contribute to facilitate the consumption of more vegetables in later childhood in obesity prone normal weight children.

Originalsprog Engelsk
Tidsskrift PLoS One
Vol/bind 13
Udgave nummer 7
Sider (fra-til) e0200388
ISSN 1932-6203
DOI
Status Udgivet - 2018

Early phase and adaptive design clinical trials in rheumatoid arthritis: a systematic review of early phase trials

Pickles, T., Christensen, R., Tam, L-S., Simon, L. S. & Choy, E. H., 2018, I : Rheumatology Advances in Practice. 2, 2, s. rky045

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Objective: Adaptive designs can enable highly sophisticated and efficient early phase trials, but the clinical inference from these trials is surrounded by complexity, and currently there is a paucity but steadily increasing amount of use of these designs in all fields of medicine. We aim to review early phase trials in RA to discover those that have used adaptive designs and benchmark trial characteristics.

Methods: From an OVID search for journal articles reporting the results of early phase trials in rheumatology, 35 studies were found, with 9 subsequently excluded; 11 were added from manual searches and 19 from searching the references. Study characteristics were extracted from the 56 papers (describing 62 trials), including the number of arms, number of patients, the primary outcome and when it was measured.

Result: One early phase trial using an adaptive design was found. The benchmark early phase trial in RA is a phase II double-blinded randomized trial, with four arms (one control and three intervention), each with 34 patients, and ACR20 measured at 16 weeks as the primary outcome.

Conclusion: The one adaptive design reviewed here, and a simulation study found in the search, both indicate that adaptive designs can be applied to early phase trials in RA. We have described the benchmark, which the efficiency of early phase trials using an adaptive design needs to exceed. These efficient designs could drive down numbers required, time for data collection and thus cost. Changes have been suggested, but more needs to be done.

Originalsprog Engelsk
Tidsskrift Rheumatology Advances in Practice
Vol/bind 2
Udgave nummer 2
Sider (fra-til) rky045
ISSN 2514-1775
DOI
Status Udgivet - 2018

Effectiveness of the Gold Standard Programme (GSP) for smoking cessation on smokers with and without a severe mental disorder: a Danish cohort study

Rasmussen, M., Klinge, M., Krogh, J., Nordentoft, M. & Tønnesen, H., 11 jun. 2018, I : BMJ Open. 8, 6, s. e021114

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

OBJECTIVES: We compared the effectiveness of an intensive smoking cessation intervention among smokers with and without a severe mental disorder (SMD) and identified factors associated with successful quitting. The main hypothesis was that smokers with an SMD would be less likely to stay continuously smoke-free for 6 months.

DESIGN: A prospective cohort study.

SETTING: In all, 302 smoking cessation clinics in Denmark from municipal clinics, pharmacies, hospitals, midwives, primary care facilities and other private providers who reported data to the national Danish Smoking Cessation Database from 2006 to 2016 participated in this study.

PARTICIPANTS: A total of 38 293 patients from the Danish Smoking Cessation Database. Patients with an SMD were identified by linking data to the Danish National Patient Register. Diagnoses of organic mental disorders (F0 chapter) or intellectual disabilities (F7 chapter) were not included. Smokers ≥18 years old who were attending a Gold Standard Programme (GSP) with planned follow-up were included. Smokers not wanting contact after 6 months were excluded.

INTERVENTIONS: A comprehensive manual-based smoking cessation intervention comprising five meetings over a 6-week period (the GSP).

MAIN OUTCOME MEASURES: Self-reported continuous abstinence at the 6-month follow-up.

RESULTS: In all, 69% of the participants participated in the follow-up after 6 months. The overall rate of successful quitting was high but significantly lower in SMD smokers (29% vs 38%; OR 0.74; 95% CI 0.68 to 0.80). Variables associated with successful quitting were compliance (defined as attending ≥75% of the planned meetings), older age and male gender as well as not being disadvantaged, heavy smoking or recommendation of intervention by health professionals.

CONCLUSIONS: Only 29% of smokers with an SMD successfully quit smoking which was significantly lower than the 38% of smokers without an SMD. Compliance was the most important predictor for successful quitting.

Originalsprog Engelsk
Tidsskrift BMJ Open
Vol/bind 8
Udgave nummer 6
Sider (fra-til) e021114
ISSN 2044-6055
DOI
Status Udgivet - 11 jun. 2018

Effects of Lifestyle on Muscle Strength in a Healthy Danish Population

Bartels, E. M., Robertson, S., Danneskiold-Samsøe, B., Appleyard, M. & Stockmarr, A., jan. 2018, I : Journal of lifestyle medicine. 8, 1, s. 16-22 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Background: Lifestyle is expected to influence muscle strength. This study aimed at assessing a possible relationship between smoking, alcohol intake and physical activity, and muscle strength in a healthy Danish population aged 20-79 years. Population study based on data collected from The Copenhagen City Heart Study (CCHS) and measurements of Isokinetic muscle strength from a sub-study of randomly selected healthy participants from CCHS.

Methods: 126 women and 63 men were studied. All participants completed a questionnaire regarding their lifestyle, including physical activity, alcohol intake and smoking habits. Isokinetic muscle strength was measured over the upper extremities (UE), trunk, and lower extremities (LE). Multivariate analyses including all of the variables were carried out.

Results: The level of daily physical activity during leisure was positively correlated to muscle strength in the lower extremities (p = 0.03) for women, and lower extremities (p = 0.03) and trunk (p = 0.007) for men. Alcohol Intake was in general not correlated to muscle strength. No clear effect of smoking was seen on muscle strength.

Conclusion: Our results show that physical activity during leisure is associated with a positive effect on muscle strength in both sexes. When keeping alcohol intake within the recommended limits, alcohol does not seem to affect muscle strength negatively. No effect of smoking on muscle strength was found in our group of healthy subjects. The findings are of importance when considering recommendation on life style when wishing to keeping fit with age to be able to carry out daily activities.

Originalsprog Engelsk
Tidsskrift Journal of lifestyle medicine
Vol/bind 8
Udgave nummer 1
Sider (fra-til) 16-22
Antal sider 7
ISSN 2234-8549
DOI
Status Udgivet - jan. 2018

Pages