Published in 2002

Blood pressure in acute stroke. The Copenhagen Stroke Study

Jørgensen, H. S., Nakayama, H., Christensen, H. R., Raaschou, H. O., Kampmann, J. P. & Olsen, T. S., 2002, I: Cerebrovascular diseases (Basel, Switzerland). 13, 3, s. 204-9 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

This study examines blood pressure (BP) and independent factors related to BP in the acute phase of stroke. The study is part of the community-based Copenhagen Stroke Study. In a multivariate regression model we analyzed the impact of clinical and medical factors on admission BP. BP declined with increasing time from stroke onset with a total of 8/4 mm Hg. Independent factors related to diastolic BP were ischemic heart disease (-3.9 mm Hg), male gender (2.2 mm Hg), known hypertension prior to stroke (8.6 mm Hg), and primary hemorrhage (9.7 mm Hg). Independent factors related to systolic BP were age (3.6 mm Hg/10-year increase), atrial fibrillation (-7.2 mm Hg), ischemic heart disease (-6.0 mm Hg), intracerebral hemorrhage (13.3 mm Hg), and known hypertension prior to stroke (16.3 mm Hg). No independent relations were seen between BP and diabetes, claudication, previous stroke, smoking, daily alcohol consumption, initial stroke severity and lesion size. The increase in BP in the acute phase of stroke is a uniform response to the ischemic event per se. BP is not related to stroke severity. Several factors are independently related to the BP level in acute stroke. The clinical significance of this is yet to be tested, but these factors may contribute to the seemingly complex relation between BP and outcome.

Originalsprog Engelsk
Tidsskrift Cerebrovascular diseases (Basel, Switzerland)
Vol/bind 13
Udgave nummer 3
Sider (fra-til) 204-9
Antal sider 6
ISSN 1015-9770
DOI
Status Udgivet - 2002

Bone mineral content and bone metabolism during physiological GH treatment in GH-deficient adults--an 18-month randomised, placebo-controlled, double blinded trial

Sneppen, S. B., Hoeck, H. C., Kollerup, G., Sørensen, O. H., Laurberg, P. & Feldt-Rasmussen, U., feb. 2002, I: European Journal of Endocrinology. 146, 2, s. 187-95 9 s.

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OBJECTIVE: To evaluate the effect of physiological adult growth hormone (GH) replacement on bones.

DESIGN: Thirty-six prospective severely growth hormone-deficient (GHD) adults (22 females and 14 males) were randomised to either 18 months of GH (0.03 mU/kg/day) or placebo treatment.

METHODS: Bone mineral density and content (BMD, BMC) and body composition were evaluated by dual energy X-ray absorptiometry at baseline and after 6, 12 and 18 months. Serum concentrations of insulin-like growth factor-I (IGF-I), IGF binding protein 3, osteocalcin, carboxyterminal propeptide of type I collagen, carboxyterminal crosslink telopeptide of type I collagen, amino-terminal propeptide of type III procollagen and urine pyridinolin and deoxypyridinolin were determined.

RESULTS: IGF-I levels increased from 63.2 microg/l (+/-10.1) to 193.6 (+/- 25.8) microg/l (mean (+/-s.e.)) (P<0.001 compared with placebo). Markers of bone turnover increased significantly from 142% to 227% of baseline values (all P<0.001 compared with placebo). Body composition changes were an increase of lean body mass and a decrease of fat mass resulting in a reduction of percentage body fat of +/- 1.8 (+/- 3.8) in the GH-treated group vs an increase of 1.0 (+/-2.9)) in the placebo-treated group (P=0.002).

CONCLUSIONS: No significant difference in BMD or BMC between the GH and placebo groups was found after 18 months. At several sites the variances of changes from baseline were significantly greater in the GH than in the placebo group, indicating an impact of the treatment. From baseline to 6 months an insignificant reduction of total BMD was seen while an increase of BMD was found from 6 to 18 months in the GH group compared with the placebo group. This placebo-controlled trial confirmed the longer term open studies on the effect on bones in patients with GHD, with an initial overrepresentation of bone resorption followed by an increase in BMD which at 18 months had reached baseline level.

Originalsprog Engelsk
Tidsskrift European Journal of Endocrinology
Vol/bind 146
Udgave nummer 2
Sider (fra-til) 187-95
Antal sider 9
ISSN 0804-4643
DOI
Status Udgivet - feb. 2002

Chalkley estimates of angiogenesis in early breast cancer--relevance to prognosis

Danish Breast Cancer Cooperative Group Tumour Biology Committee, 2002, I: Acta Oncologica. 41, 7-8, s. 695-703 9 s.

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Effect of preoperative smoking intervention on postoperative complications: a randomised clinical trial

Møller, A., Villebro, N. M., Pedersen, T. & Tønnesen, H., 12 jan. 2002, I: Lancet. 359, 9301, s. 114-7 4 s.

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Smokers are at higher risk of cardiopulmonary and wound-related postoperative complications than non-smokers. Our aim was to investigate the effect of preoperative smoking intervention on the frequency of postoperative complications in patients undergoing hip and knee replacement.
Originalsprog Engelsk
Tidsskrift Lancet
Vol/bind 359
Udgave nummer 9301
Sider (fra-til) 114-7
Antal sider 4
ISSN 0140-6736
DOI
Status Udgivet - 12 jan. 2002

OBJECTIVE: To investigate the time relation between dementia and major affective disorders (major depression and mania).

METHODS: Register linkage study of the Danish Hospital Register and the Danish Psychiatric Central Research Register, to establish study cohorts of patients with dementia and control groups (osteoarthritis or diabetes) on first discharge from hospital. Follow up of cohorts was for up to 21 years. Hazard of death was allowed for by the use of competing risks models.

RESULTS: Patients with dementia had an increased risk of being admitted to hospital for major depression or mania during the course of the illness. The incidence remained elevated throughout the rest of the patient's life.

CONCLUSIONS: Patients with dementia have an increased risk of developing depression or mania. Proper treatment of affective disorders in patients with dementia is important in reducing suffering and costs.

Originalsprog Engelsk
Tidsskrift Journal of neurology, neurosurgery, and psychiatry
Vol/bind 73
Udgave nummer 1
Sider (fra-til) 40-4
Antal sider 5
ISSN 0022-3050
Status Udgivet - jul. 2002

Factors associated with asthma in young Danish adults

Backer, V., Nepper-Christensen, S., Ulrik, C. S., von Linstow, M-L. & Porsbjerg, C., aug. 2002, I: Annals of Allergy, Asthma, & Immunology. 89, 2, s. 148-54 7 s.

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Impaired postoperative outcome in chronic alcohol abusers after curative resection for lung cancer

Neuenschwander, A. U., Pedersen, J. H., Krasnik, M. & Tønnesen, H., 2002, I: European Journal of Cardio-thoracic Surgery. 22

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Originalsprog Engelsk
Tidsskrift European Journal of Cardio-thoracic Surgery
Vol/bind 22
ISSN 1010-7940
Status Udgivet - 2002

Influence of DRG system on patient conditioning

Tønnesen, H., 2002, I: Journal für Anästhesie und Intensivbehandlung.

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Originalsprog Engelsk
Tidsskrift Journal für Anästhesie und Intensivbehandlung
Status Udgivet - 2002

Klinisk Enhed for Sygdomsforebyggelse

Bendix, A. F. & Tønnesen, H., 2002, I: Månedsskr Prakt Lægegern. 80

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Originalsprog Dansk
Tidsskrift Månedsskr Prakt Lægegern
Vol/bind 80
ISSN 0373-2746
Status Udgivet - 2002

Nerve conduction studies in selected peripheral nerve disorders

Krarup, C., okt. 2002, I: Current Opinion in Neurology. 15, 5, s. 579-93 15 s.

Publikation: Bidrag til tidsskriftReviewpeer review

Preoperative smoking intervention and postoperative complications

Møller, A. M., Villebro, N., Pedersen, T. & Tønnesen, H., 2002, I: Journal für Anästhesie und Intensivbehandlung. 9

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Originalsprog Engelsk
Tidsskrift Journal für Anästhesie und Intensivbehandlung
Vol/bind 9
Status Udgivet - 2002

Recording of postoperative complications: quantity and quality

Maina, P., Carstensen, M. & Tønnesen, H., 1 jan. 2002, I: The European journal of surgery = Acta chirurgica. 168, 12, s. 736-40 5 s.

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To evaluate a simple working procedure for recording postoperative complications.
Originalsprog Engelsk
Tidsskrift The European journal of surgery = Acta chirurgica
Vol/bind 168
Udgave nummer 12
Sider (fra-til) 736-40
Antal sider 5
ISSN 1102-4151
Status Udgivet - 1 jan. 2002

Staphylococcus aureus: colonizing features and influence of an antibacterial treatment in adults with atopic dermatitis

Breuer, K., HAussler, S., Kapp, A. & Werfel, T., jul. 2002, I: British Journal of Dermatology. 147, 1, s. 55-61 7 s.

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Vedrørende Det Nationale Råd for Laegers Videreuddannelses beslutning om nedlaeggelse af grenspecialet klinisk neurofysiologi

Krarup, C., 18 mar. 2002, I: Ugeskrift for Laeger. 164, 12, s. 1667-8 2 s.

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Published in 2001

Acute gastroparesis secondary to thyrotoxicosis

Von Linstow, M. L. & Vadstrup, S., 2001, I: Archives of Gastroenterohepatology. 20, 1-2, s. 44-47 4 s.

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Alkohols betydning for postoperative komplikationer

Tønnesen, H., 2001, Rygning & alkohol og operationer. Sundhedsstyrelsen

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskningpeer review

Originalsprog Dansk
Titel Rygning & alkohol og operationer
Forlag Sundhedsstyrelsen
Publikationsdato 2001
Status Udgivet - 2001

Atopi hos børn og unge i København

Ulrik, C. S., von Linstow, M. L. & Backer, V., 10 dec. 2001, I: Ugeskrift for Laeger. 163, 50, s. 7070-3 4 s.

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Cholecystokinin gene transcription: promoter elements, transcription factors and signaling pathways

Hansen, T. V., aug. 2001, I: Peptides. 22, 8, s. 1201-11 11 s.

Publikation: Bidrag til tidsskriftReviewpeer review

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