Published in 2004

Antidepressiva til hjaelp til rygestop

Møller, A. & Tønnesen, H., 11 okt. 2004, I: Ugeskrift for Laeger. 166, 42, s. 3697-9 3 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

Bidragets oversatte titel [Antidepressants for smoking cessation]
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 166
Udgave nummer 42
Sider (fra-til) 3697-9
Antal sider 3
ISSN 0041-5782
Status Udgivet - 11 okt. 2004

Forebyggelse før planlagt operation

Tønnesen, H., 13 sep. 2004, I: Ugeskrift for Laeger. 166, 38, s. 3281

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

Bidragets oversatte titel [Prevention in elective surgery]
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 166
Udgave nummer 38
Sider (fra-til) 3281
ISSN 0041-5782
Status Udgivet - 13 sep. 2004

Forebyggelsessamtaler. Har de en plads på en akutafdeling?

Nelbom, B. M., Tønnesen, H. & Backer, V., 9 aug. 2004, I: Ugeskrift for Laeger. 166, 33, s. 2791-5 5 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

Bidragets oversatte titel [Motivational counseling. Possible in an emergency department?]
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 166
Udgave nummer 33
Sider (fra-til) 2791-5
Antal sider 5
ISSN 0041-5782
Status Udgivet - 9 aug. 2004

Impact of the sex of first child on the prognosis in secondary recurrent miscarriage

Christiansen, O. B., Pedersen, B., Nielsen, H. S. & Nybo Andersen, A-M., dec. 2004, I: Human reproduction (Oxford, England). 19, 12, s. 2946-51 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

BACKGROUND: The carriage of a male fetus often initiates maternal immunological reactions against male-specific minor histocompatibility (HY) antigens, which, in theory, could result in subsequent recurrent miscarriage (RM).

METHODS: Information about subsequent pregnancy outcome was procured among 182 women with RM after a birth (secondary RM) referred since 1986 using questionnaires, telephone interviews and registers.

RESULTS: Significantly more of the women had had a male first-born as compared with a female first-born (110 versus 72; P < 0.02). By January 2002, 58% of those who had a male first-born had given birth to a second live infant compared with 76% of those who previously had had a female first-born (P = 0.01). Women in the former group had a significantly lower chance of having a second child than those in the latter (adjusted hazard ratio 0.59; 95% confidence interval 0.41-0.86). The number of miscarriages after admission and the risk of secondary infertility were significantly greater in women with a male first-born than among those with a female first-born (P < 0.001 and P = 0.02; respectively).

CONCLUSIONS: A male first-born seems to be associated with a less favourable reproductive potential among women with secondary RM. Maternal immunization against HY antigens may be responsible for these findings.

Originalsprog Engelsk
Tidsskrift Human reproduction (Oxford, England)
Vol/bind 19
Udgave nummer 12
Sider (fra-til) 2946-51
Antal sider 6
ISSN 0268-1161
DOI
Status Udgivet - dec. 2004

Plasma TNF binding capacity profiles during treatment with etanercept in rheumatoid arthritis

Gudbrandsdottir, S., Bliddal, H., Petri, A., Terslev, L., Danneskiold-Samsøe, B., Bjørnhart, B., Bendtzen, K. & Müller, K., 1 jan. 2004, I: Scandinavian Journal of Rheumatology. 33, 6, s. 385-8 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Etanercept (Enbrel) induces a rapid and sustained decline in disease activity in the majority of patients with refractory rheumatoid arthritis (RA). In these patients neutralization of TNFalpha and lymphotoxin (LT), previously termed TNFbeta is mediated by etanercept itself, as well as by naturally occurring soluble TNF receptors. However, the clinical response to treatment with etanercept may vary. Previously, pharmacokinetic studies have focused on the molar concentrations of etanercept, but very little is known about the kinetics of bioactive etanercept in patients treated with etanercept. The purpose of this study was to evaluate kinetics, including inter- and intraindividual variations of the total TNF binding capacity, in RA patients who were on a standard treatment schedule with etanercept.
Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rheumatology
Vol/bind 33
Udgave nummer 6
Sider (fra-til) 385-8
Antal sider 4
ISSN 0300-9742
Status Udgivet - 1 jan. 2004

Rygestop og kronisk obstruktiv lungesygdom

Møller, A. & Tønnesen, H., 11 okt. 2004, I: Ugeskrift for Laeger. 166, 42, s. 3695-7 3 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

Bidragets oversatte titel [Smoking cessation and chronic obstructive pulmonary disease]
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 166
Udgave nummer 42
Sider (fra-til) 3695-7
Antal sider 3
ISSN 0041-5782
Status Udgivet - 11 okt. 2004

Rygestop på arbejdspladsen

Tønnesen, H. & Møller, A. M., 11 okt. 2004, I: Ugeskrift for Laeger. 166, 42, s. 3700-2 3 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

Bidragets oversatte titel [Workplace smoking cessation]
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 166
Udgave nummer 42
Sider (fra-til) 3700-2
Antal sider 3
ISSN 0041-5782
Status Udgivet - 11 okt. 2004

Systematisk alkoholintervention på sygehus

Mortensen, T. L. & Tønnesen, H., 13 sep. 2004, I: Ugeskrift for Laeger. 166, 38, s. 3284-9 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

Bidragets oversatte titel [Systematic alcohol intervention in hospitals]
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 166
Udgave nummer 38
Sider (fra-til) 3284-9
Antal sider 6
ISSN 0041-5782
Status Udgivet - 13 sep. 2004

Test-retest reliability of trunk accelerometric gait analysis

Henriksen, M., Lund, H., Moe-Nilssen, R., Bliddal, H. & Danneskiold-Samsøe, B., jun. 2004, I: Gait & posture. 19, 3, s. 288-97 10 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The purpose of this study was to determine the test-retest reliability of a trunk accelerometric gait analysis in healthy subjects. Accelerations were measured during walking using a triaxial accelerometer mounted on the lumbar spine of the subjects. Six men and 14 women (mean age 35.2; range 18-57) underwent the same protocol on 2 consecutive days. The raw acceleration signals from six self-selected walking speeds were transformed into a horizontal-vertical coordinate system to remove unwanted variability caused by gravity. Acceleration root mean square values, cadences, step and stride lengths were then computed and interpolated using quadratic curve fits and point estimates were calculated at a standardised walking speed of 1.35 m/s. Relative reliability was determined using two models of intraclass correlation coefficients (ICC(1,1) and ICC(3,1)) to assess any systematic shifts and absolute reliability was determined using measurement error (ME). The results of the study showed high ICC values (0.77-0.96) and ME values of 0.007-0.01 g for mean acceleration; 0.009 m for step lengths; 0.022 m for stride length and 1.644 step/min for cadences. In conclusion, the method was found to be reliable and may have a definite potential in clinical gait analysis.

Originalsprog Engelsk
Tidsskrift Gait & posture
Vol/bind 19
Udgave nummer 3
Sider (fra-til) 288-97
Antal sider 10
ISSN 0966-6362
DOI
Status Udgivet - jun. 2004

Vitamin D insufficiency in Greenlanders on a westernized fare: ethnic differences in calcitropic hormones between Greenlanders and Danes

Rejnmark, L., Hansen, J. C., Heickendorff, L., Lauridsen, A. L., Mulvad, G., Siggaard, C., Skjoldborg, H., Sørensen, T. B., Pedersen, E. B., Mosekilde, L. & Jørgensen, M. E., mar. 2004, I: Calcified Tissue International. 74, 3, s. 255-63 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

We studied the influence of age, gender, latitude, season, diet and ethnicity on plasma 25-hydroxyvitamin D 25 OHD, PTH, 1,25-dihydroxyvitamin D, vitamin D-binding protein, bone-specific alkaline phosphatase, and osteocalcin levels in 46 Greenlanders living in Nuuk (64 degrees N) on a traditional fare (group A), 45 Greenlanders living in Nuuk on a westernized fare (group B), 54 Greenlanders (group C), and 43 Danes (Group D) living in Denmark (55 degrees N) on a westernized fare. Blood specimens were drawn both summer and winter. Vitamin D insufficiency (plasma 25 OHD <40 nmol/l) was common in all four study groups during summer (23-74%) and winter (42-81%). Compared to groups A and D, vitamin D insufficiency was significantly more frequent in groups B and C. In all groups, summer levels of 25 OHD were above winter levels. Multiple regression analysis revealed a significant effect of ethnicity. Compared to Danes, Greenlanders had higher 1,25-dihydroxyvitamin D levels, but lower 25 OHD and PTH levels despite relatively low plasma calcium concentrations. In addition to ethnicity, 25(OH)D levels were influenced by age, season (summer > winter), and diet (a traditional Inuit diet>westernized diet). Ethnic differences exist between Greenlanders and Danes. Our results suggest that Greenlanders may have an inherent lower "set-point" for calcium-regulated PTH release or an enhanced renal 1,25(OH)(2)D production. In addition to ethnicity, age, season, and diet were important determinants of vitamin D status. Changes from a traditional to a westernized fare are associated with a reduced vitamin D status in Greenlanders. Vitamin D supplementation should be considered.

Originalsprog Engelsk
Tidsskrift Calcified Tissue International
Vol/bind 74
Udgave nummer 3
Sider (fra-til) 255-63
Antal sider 9
ISSN 0171-967X
DOI
Status Udgivet - mar. 2004

Published in 2003

Affective disorders in neurological diseases: a case register-based study

Nilsson, F. M., Kessing, L. V., Sørensen, T. M., Andersen, P. K. & Bolwig, T. G., jul. 2003, I: Acta Psychiatrica Scandinavica. 108, 1, s. 41-50 10 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

OBJECTIVE: To investigate the temporal relationships between a range of neurological diseases and affective disorders.

METHOD: Data derived from linkage of the Danish Psychiatric Central Register and the Danish National Hospital Register. Seven cohorts with neurological index diagnoses and two control group diagnoses were followed for up to 21 years. The incidences of affective disorders in the different groups were compared with the control groups, using competing risks to consider the risk of affective disorder and the risk of death in the same analysis.

RESULTS: We found an increased incidence of affective disorders in dementia, Parkinson's disease, epilepsy, stroke and intracerebral haemorrhage compared with control groups. The association was found to be the strongest for dementia and Parkinson's disease. In hospitalized patients, with incident multiple sclerosis, the incidence of affective disorder was lower than the incidence in the control groups.

CONCLUSION: In neurological diseases there seems to be an increased incidence of affective disorders. The elevated incidence was found to be particularly high for dementia and Parkinson's disease (neurodegenerative diseases).

Originalsprog Engelsk
Tidsskrift Acta Psychiatrica Scandinavica
Vol/bind 108
Udgave nummer 1
Sider (fra-til) 41-50
Antal sider 10
ISSN 0001-690X
Status Udgivet - jul. 2003

Alkohol – forebyggelse på sygehus. Fakta, Metoder og anbefalinger

Mundt, K., Jensen, M., Kann, A., Nielsen, A. S., Grønbaek, M. & Tønnesen, H., 2003, København: Clinical Unit of Health Promotion.

Publikation: Bog/antologi/afhandling/rapportBogForskning

Originalsprog Dansk
Udgivelsessted København
Forlag Clinical Unit of Health Promotion
Status Udgivet - 2003

Effects of intravenous fluid restriction on postoperative complications: comparison of two perioperative fluid regimens: a randomized assessor-blinded multicenter trial

Brandstrup, B., Tønnesen, H., Beier-Holgersen, R., Hjortsø, E., Ørding, H., Larsen, K. L., Rasmussen, M. S., Lanng, C., Wallin, L., Iversen, L. H., Gramkow, C. S., Okholm, M., Blemmer, T., Svendsen, P-E., Rottensten, H. H. F., Thage, B., Riis, J. J., Jeppesen, I., Teilum, D., Christensen, A. M., & 3 flereGraungaard, B., Pott, F. C. & Danish Study Group on Perioperative Fluid Therapy, 1 nov. 2003, I: Annals of Surgery. 238, 5, s. 641-8 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

To investigate the effect of a restricted intravenous fluid regimen versus a standard regimen on complications after colorectal resection.
Originalsprog Engelsk
Tidsskrift Annals of Surgery
Vol/bind 238
Udgave nummer 5
Sider (fra-til) 641-8
Antal sider 8
ISSN 0003-4932
DOI
Status Udgivet - 1 nov. 2003

Livsstil og forebyggelse på sygehuse. Ekspertvaelde eller patienternes ret

Fugleholm, A. M. & Tønnesen, H., 10 mar. 2003, I: Ugeskrift for Laeger. 165, 11, s. 1121-3 3 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

Bidragets oversatte titel [Life style and prevention in hospitals. The power of experts or patient rights]
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 165
Udgave nummer 11
Sider (fra-til) 1121-3
Antal sider 3
ISSN 0041-5782
Status Udgivet - 10 mar. 2003

Operation. Komplikationer kan forebygges

Jørgensen, S. J., Hansen, H. V., Hessov, I., Lauritsen, J. B., Madelung, S. & Tønnesen, H., 2003, København: Clinical Unit of Health Promotion.

Publikation: Bog/antologi/afhandling/rapportBogForskning

Originalsprog Dansk
Udgivelsessted København
Forlag Clinical Unit of Health Promotion
Status Udgivet - 2003

TNF-alpha-blokker-behandling af artrit--fire års opfølgning

Petri, A., Dreyer, L., Danneskiold-Samsøe, B., Terslev, L. & Bliddal, H., 24 nov. 2003, I: Ugeskrift for Laeger. 165, 48, s. 4649-52 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Bidragets oversatte titel Anti-TNF-alpha-treatment of arthritis--4-year follow-up
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Vol/bind 165
Udgave nummer 48
Sider (fra-til) 4649-52
Antal sider 4
ISSN 0041-5782
Status Udgivet - 24 nov. 2003

Published in 2002

Admission body temperature predicts long-term mortality after acute stroke: the Copenhagen Stroke Study

Kammersgaard, L. P., Jørgensen, H. S., Rungby, J., Reith, J., Nakayama, H., Weber, U. J., Houth, J. & Olsen, T. S. jul 2002 I : Stroke. 33, 7, s. 1759-62 4 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Body temperature is considered crucial in the management of acute stroke patients. Recently hypothermia applied as a therapy for stroke has been demonstrated to be feasible and safe in acute stroke patients. In the present study, we investigated the predictive role of admission body temperature to the long-term mortality in stroke patients.
Originalsprog Engelsk
Tidsskrift Stroke
Udgivelsesdato jul 2002
Vol/bind 33
Tidsskriftsnummer 7
Sider 1759-62
Antal sider 4
ISSN 0039-2499
Status Udgivet

Blood pressure in acute stroke. The Copenhagen Stroke Study

Jørgensen, H. S., Nakayama, H., Christensen, H. R., Raaschou, H. O., Kampmann, J. P. & Olsen, T. S., 2002, I: Cerebrovascular diseases (Basel, Switzerland). 13, 3, s. 204-9 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

This study examines blood pressure (BP) and independent factors related to BP in the acute phase of stroke. The study is part of the community-based Copenhagen Stroke Study. In a multivariate regression model we analyzed the impact of clinical and medical factors on admission BP. BP declined with increasing time from stroke onset with a total of 8/4 mm Hg. Independent factors related to diastolic BP were ischemic heart disease (-3.9 mm Hg), male gender (2.2 mm Hg), known hypertension prior to stroke (8.6 mm Hg), and primary hemorrhage (9.7 mm Hg). Independent factors related to systolic BP were age (3.6 mm Hg/10-year increase), atrial fibrillation (-7.2 mm Hg), ischemic heart disease (-6.0 mm Hg), intracerebral hemorrhage (13.3 mm Hg), and known hypertension prior to stroke (16.3 mm Hg). No independent relations were seen between BP and diabetes, claudication, previous stroke, smoking, daily alcohol consumption, initial stroke severity and lesion size. The increase in BP in the acute phase of stroke is a uniform response to the ischemic event per se. BP is not related to stroke severity. Several factors are independently related to the BP level in acute stroke. The clinical significance of this is yet to be tested, but these factors may contribute to the seemingly complex relation between BP and outcome.

Originalsprog Engelsk
Tidsskrift Cerebrovascular diseases (Basel, Switzerland)
Vol/bind 13
Udgave nummer 3
Sider (fra-til) 204-9
Antal sider 6
ISSN 1015-9770
DOI
Status Udgivet - 2002

Bone mineral content and bone metabolism during physiological GH treatment in GH-deficient adults--an 18-month randomised, placebo-controlled, double blinded trial

Sneppen, S. B., Hoeck, H. C., Kollerup, G., Sørensen, O. H., Laurberg, P. & Feldt-Rasmussen, U., feb. 2002, I: European Journal of Endocrinology. 146, 2, s. 187-95 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

OBJECTIVE: To evaluate the effect of physiological adult growth hormone (GH) replacement on bones.

DESIGN: Thirty-six prospective severely growth hormone-deficient (GHD) adults (22 females and 14 males) were randomised to either 18 months of GH (0.03 mU/kg/day) or placebo treatment.

METHODS: Bone mineral density and content (BMD, BMC) and body composition were evaluated by dual energy X-ray absorptiometry at baseline and after 6, 12 and 18 months. Serum concentrations of insulin-like growth factor-I (IGF-I), IGF binding protein 3, osteocalcin, carboxyterminal propeptide of type I collagen, carboxyterminal crosslink telopeptide of type I collagen, amino-terminal propeptide of type III procollagen and urine pyridinolin and deoxypyridinolin were determined.

RESULTS: IGF-I levels increased from 63.2 microg/l (+/-10.1) to 193.6 (+/- 25.8) microg/l (mean (+/-s.e.)) (P<0.001 compared with placebo). Markers of bone turnover increased significantly from 142% to 227% of baseline values (all P<0.001 compared with placebo). Body composition changes were an increase of lean body mass and a decrease of fat mass resulting in a reduction of percentage body fat of +/- 1.8 (+/- 3.8) in the GH-treated group vs an increase of 1.0 (+/-2.9)) in the placebo-treated group (P=0.002).

CONCLUSIONS: No significant difference in BMD or BMC between the GH and placebo groups was found after 18 months. At several sites the variances of changes from baseline were significantly greater in the GH than in the placebo group, indicating an impact of the treatment. From baseline to 6 months an insignificant reduction of total BMD was seen while an increase of BMD was found from 6 to 18 months in the GH group compared with the placebo group. This placebo-controlled trial confirmed the longer term open studies on the effect on bones in patients with GHD, with an initial overrepresentation of bone resorption followed by an increase in BMD which at 18 months had reached baseline level.

Originalsprog Engelsk
Tidsskrift European Journal of Endocrinology
Vol/bind 146
Udgave nummer 2
Sider (fra-til) 187-95
Antal sider 9
ISSN 0804-4643
DOI
Status Udgivet - feb. 2002

Effect of preoperative smoking intervention on postoperative complications: a randomised clinical trial

Møller, A., Villebro, N. M., Pedersen, T. & Tønnesen, H., 12 jan. 2002, I: Lancet. 359, 9301, s. 114-7 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskning

Smokers are at higher risk of cardiopulmonary and wound-related postoperative complications than non-smokers. Our aim was to investigate the effect of preoperative smoking intervention on the frequency of postoperative complications in patients undergoing hip and knee replacement.
Originalsprog Engelsk
Tidsskrift Lancet
Vol/bind 359
Udgave nummer 9301
Sider (fra-til) 114-7
Antal sider 4
ISSN 0140-6736
DOI
Status Udgivet - 12 jan. 2002

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