Published in 1998

Experimental study of oxidative DNA damage

Loft, S., Deng, X., Tuo, J., Wellejus, A., Sørensen, M. & Poulsen, H. E. dec. 1998 I : Free Radical Research. 29, 6, s. 525-39 15 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Animal experiments allow the study of oxidative DNA damage in target organs and the elucidation of dose-response relationships of carcinogenic and other harmful chemicals and conditions as well as the study of interactions of several factors. So far the effects of more than 50 different chemical compounds have been studied in animal experiments mainly in rats and mice, and generally with measurement of 8-oxodG with HPLC-EC. A large number of well-known carcinogens induce 8-oxodG formation in liver and/or kidneys. Moreover several animal studies have shown a close relationship between induction of dative DNA damage and tumour formation. In principle the level of oxidative DNA damage in an organ or cell may be studied by measurement of modified bases in extracted DNA by immunohistochemical visualisation, and from assays of strand breakage before and after treatment with repair enzymes. However, this level is a balance between the rates of damage and repair. Until the repair rates and capacity can be adequately assessed the rate of damage can only be estimated from the urinary excretion of repair products albeit only as an average of the entire body. A number of model compounds have been used to induce oxidative DNA damage in experimental animals. The hepatocarcinogen 2-nitropropane induces up to 10-fold increases in 8-oxodG levels in rat liver DNA. The level of 8-oxodG is also increased in kidneys and bone marrow but not in the testis. By means of 2-nitropropane we have shown correspondence between the increases in 8-oxodG in target organs and the urinary excretion of 8-oxodG and between 8-oxodG formation and the comet assay in bone marrow as well potent preventive effects of extracts of Brussels sprouts. Others have shown similar effects of green tea extracts and its components. Drawbacks of the use of 2-nitropropane as a model for oxidative DNA damage relate particularly to formation of 8-aminoguanine derivatives that may interfere with HPLC-EC assays and have unknown consequences. Other model compounds for induction of oxidative DNA damage, such as ferric nitriloacetate, iron dextran, potassium bromate and paraquat, are less potent and/or more organ specific. Inflammation and activation of an inflammatory response by phorbol esters or E. coli lipopolysaccharide (LPS) induce oxidative DNA damage in many target cells and enhance benzene-induced DNA damage in mouse bone marrow. Experimental studies provide powerful tools to investigate agents inducing and preventing oxidative damage to DNA and its role in carcinogenesis. So far, most animal experiments have concerned 8-oxodG and determination of additional damaged bases should be employed. An ideal animal model for prevention of oxidative DNA damage has yet to he developed.

Originalsprog Engelsk
Tidsskrift Free Radical Research
Vol/bind 29
Tidsskriftsnummer 6
Sider (fra-til) 525-39
Antal sider 15
ISSN 1071-5762
Status Udgivet - dec. 1998

Published in 1997

Double-blind, placebo-controlled cross-over study of intravenous S-adenosyl-L-methionine in patients with fibromyalgia

Volkmann, H., Nørregaard, J., Jacobsen, S., Danneskiold-Samsøe, B., Knoke, G. & Nehrdich, D. 1997 I : Scandinavian Journal of Rheumatology. 26, 3, s. 206-11 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The objective of this study was to test the efficacy of intravenously administered S-adenosyl-L-methionine (SAMe) in patients with fibromyalgia (FM). Thirty-four out-patients with fibromyalgia symptoms received SAMe 600 mg i.v. or placebo daily for 10 days in a cross-over trial. There was no significant difference in improvement in the primary outcome: tender point change between the two treatment groups. There was a tendency towards statistical significance in favour of SAMe on subjective perception of pain at rest (p = 0.08), pain on movement (p = 0.11), and overall well-being (p = 0.17) and slight improvement only on fatigue, quality of sleep, morning stiffness, and on the Fibromyalgia Impact Questionnaire for pain. No effect could be observed on isokinetic muscle strength, Zerrsen self-assessment questionnaire, and the face scale. No effect of SAMe in patients with FM was found in this short term study.
Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rheumatology
Vol/bind 26
Tidsskriftsnummer 3
Sider (fra-til) 206-11
Antal sider 6
ISSN 0300-9742
Status Udgivet - 1997

Muscle strength, working capacity and effort in patients with fibromyalgia

Nørregaard, J., Bülow, P. M., Lykkegaard, J. J., Mehlsen, J. & Danneskiold-Samsøoe, B. 1 jun. 1997 I : Scandinavian Journal of Rehabilitation Medicine. 29, 2, s. 97-102 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The objective of the study was to evaluate the physical capacity and effort in patients with fibromyalgia. Muscle strength and the coefficient of variation of the strength measurements of 181 female fibromyalgia patients and 126 healthy females were compared. These measurements and ergometer exercise capacity, work status and psychometric scoring (SCL-90-R) were correlated. The fibromyalgia patients exhibited significant reduction in voluntary muscle strength of the knee and elbow, flexors and extensors in the order of 20-30%. However, the coefficient of variation was higher among patients, thus indicating lower effort. The physical performance during an ergometer test corresponded to a maximal oxygen consumption of 21 ml/kg-1 x min-1. The maximal increase in heart rate was only 63% (44-90%) of the predicted increase. Degree of effort or physical capacity did not correlate to psychometric scores. Work status was related to psychometric scoring, but not to physical capacity or effort. In conclusion, we found a low degree of effort but near normal physical capacity in the fibromyalgia patients.
Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rehabilitation Medicine
Vol/bind 29
Tidsskriftsnummer 2
Sider (fra-til) 97-102
Antal sider 6
ISSN 0036-5505
Status Udgivet - 1 jun. 1997

Published in 1995

Behandling af højt blodtryk hos patienter med akut apopleksi

Olsen, T. S., Jørgensen, H. S., Garde, E. & Lassen, N. A. 19 jun 1995 I : Ugeskrift for Laeger. 157, 25, s. 3623-5 3 s.

Publikation: Forskning - peer reviewTidsskriftartikel

The study was performed to investigate how often reduction of high blood pressure (> or = 220 mmHg systolic and or > or = 120 mmHg diastolic) was attempted in patients with acute stroke or transient ischemic attacks (TIA). Of 1351 consecutive patients with acute stroke or TIA 119 had high blood pressure on admission. In 15 patients the stroke was so severe that treatment was not considered. In the remaining 104 patients reduction of the blood pressure was attempted in 28 (27%); in 23 patients immediately following admission. None of the patients had symptoms or signs of hypertensive encephalopathy. It is concluded that reduction of high blood pressure in patients with stroke or TIA is attempted too often. As autoregulation is commonly impaired in acute stroke, reduction of systemic blood pressure may enhance ischaemic tissue damage. Reduction of blood pressure in acute stroke should be considered only in case of hypertensive encephalopathy.
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Udgivelsesdato 19 jun 1995
Vol/bind 157
Tidsskriftsnummer 25
Sider 3623-5
Antal sider 3
ISSN 0041-5782
Status Udgivet

Blodtryksnedsaettelse kan forvaerre symptomerne ved akut apopleksi

Garde, E., Jørgensen, H. S., Olsen, T. S. & Lassen, N. A. 19 jun 1995 I : Ugeskrift for Laeger. 157, 25, s. 3630-1 2 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Patients with acute stroke often present with high blood pressure (BP) on hospital admission. Because hypertension is a risk factor for stroke, and because severe BP elevation may increase oedema and the risk of haemorrhage, acute antihypertensive therapy might seem reasonable. On the other hand, the increase in BP in the acute stage might be considered a beneficial pathophysiological response maintaining the perfusion pressure to the ischaemic area and, in particular, the surrounding penumbra. As illustrated in the case presented here, lowering the BP in the early stage may be associated with progression of neurological deficits, very likely due to a reduction of perfusion to the penumbra thus enlarging the infarct.
Originalsprog Dansk
Tidsskrift Ugeskrift for Laeger
Udgivelsesdato 19 jun 1995
Vol/bind 157
Tidsskriftsnummer 25
Sider 3630-1
Antal sider 2
ISSN 0041-5782
Status Udgivet

The twitch interpolation technique for study of fatigue of human quadriceps muscle

Bülow, P. M., Nørregaard, J., Mehlsen, J. & Danneskiold-Samsøe, B. 1 nov. 1995 I : Journal of Neuroscience Methods. 62, 1-2, s. 103-9 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The aim of the study was to examine if the twitch interpolation technique could be used to objectively measure fatigue in the quadriceps muscle in subjects performing submaximally. The 'true' maximum isometric quadriceps torque was determined in 21 healthy subject using the twitch interpolation technique. Then an endurance test was performed in which the subjects made repeated isometric contractions at 50% of the 'true' maximum torque for 4 s, separated by 6 s rest periods. During the test, the force response to single electrical stimulation (twitch amplitude) was measured at 50% and 25% of the estimated maximum torque. In 10 subjects, the test was repeated 2-4 weeks later. Twitch amplitudes at 50% of maximum torque declined exponentially with time in 20 of 21 subjects. The distribution of the exponential rate constant was skewed with a mean of 4.6 h-1 and range of 0.3-21.5 h-1. After logarithmical transformation, the distribution of the exponential rate constant fitted closely to a normal distribution, and the inter-individual variation was SD = 1.15 compared to an intra-individual variation of 0.29. The coefficient of correlation for repeated determination was 0.91 (P <0.001, n = 10). In conclusion, the twitch technique can be used for objectively measuring fatigue of the quadriceps muscle.
Originalsprog Engelsk
Tidsskrift Journal of Neuroscience Methods
Vol/bind 62
Tidsskriftsnummer 1-2
Sider (fra-til) 103-9
Antal sider 7
ISSN 0165-0270
Status Udgivet - 1 nov. 1995

Published in 1994

Absence of vasoactive peptide release from brain to cerebral circulation during onset of migraine with aura

Friberg, L., Olesen, J., Olsen, T. S., Karle, A., Ekman, R. & Fahrenkrug, J. feb. 1994 I : Cephalalgia. 14, 1, s. 47-54 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

In eight patients carotid angiography was required for evaluation of transient neurological attacks. Cerebral blood flow results, angiography and clinical observations subsequently suggested the diagnosis of migraine. We measured plasma concentrations of substance P(SP), neuropeptide Y (NPY), calcitonin gene-related peptide (CGRP) and vasoactive intestinal peptide (VIP) in repeated blood samples obtained from the carotid artery and the internal jugular vein in conjunction with cerebral angiography followed by 4 to 6 repeated recordings of regional cerebral blood flow (rCBF) with the intracarotid Xenon-133 injection technique. This technique is known to induce attacks of migraine with aura in many sufferers. Four patients developed aura symptoms. In three this was succeeded by throbbing headache. Typical, migraine-related, focal hypoperfusion occurred in conjunction with the aura symptoms. The remaining four patients had no symptoms or rCBF changes. There were no systematic or statistically significant changes over time in arterial-venous plasma concentrations or in the release rates of any of the peptides. All migraineurs had an overall elevated mean CGRP value compared to control values from the literature. The overall plasma levels of the potent vasoconstrictor NPY were higher (p <0.10) in the group that developed symptoms and rCBF changes (136 pmol/l) than in the non-symptomatic group (97 pmol/l). The difference in NPY levels could perhaps be associated with the focal rCBF decrease seen in the attack group.
Originalsprog Engelsk
Tidsskrift Cephalalgia
Vol/bind 14
Tidsskriftsnummer 1
Sider (fra-til) 47-54
Antal sider 8
ISSN 0333-1024
Status Udgivet - feb. 1994

Biochemical changes in relation to a maximal exercise test in patients with fibromyalgia

Nørregaard, J., Bülow, P. M., Mehlsen, J. & Danneskiold-Samsøe, B. 1 mar. 1994 I : Clinical Physiology and Functional Imaging. 14, 2, s. 159-67 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Patients with fibromyalgia often complain of fatigue and pain during exercise and of worsening of pain days after exercise. The aim of the study described here was to determine if abnormal changes in potassium or lactate could be observed during an exercise test in fibromyalgia. Whether an abnormal incline in plasma creatine kinase or myoglobin could be observed days after the test was studied also. Fifteen female fibromyalgia patients and 15 age- and sex-matched controls performed a stepwise incremental maximal bicycle-ergometer test. Blood samples were collected from a catheter in a cubital vein. The changes in heart rate, potassium levels, and haematocrit during the exercise test were similar in the two groups. The maximal obtained lactate concentration was 4.2 mmol l-1 (3.5-5.6) in the patients as compared to 4.9 mmol l-1 (3.9-5.9) in the controls (NS). The estimated anaerobic threshold of 2 mmol l-1 was reached at a heart rate of 124 min-1 in the patients with fibromyalgia as compared to 140 min-1 in the controls (P = 0.02). In relation to workload, the patients scored higher on a Borg scale for perceived exertion during exercise, but if the Borg score was related to lactate no significant difference was found. The patients reported 86% and 79% of maximal pain in the thighs on the visual analogue scale 1 and 2 days after the test, but the creatine kinase and myoglobin concentrations were not increased.
Originalsprog Engelsk
Tidsskrift Clinical Physiology and Functional Imaging
Vol/bind 14
Tidsskriftsnummer 2
Sider (fra-til) 159-67
Antal sider 9
ISSN 1475-0961
Status Udgivet - 1 mar. 1994

Cerebral oxygen extraction, oxygen consumption, and regional cerebral blood flow during the aura phase of migraine

Friberg, L., Olesen, J., Lassen, N. A., Olsen, T. S. & Karle, A. maj 1994 I : Stroke. 25, 5, s. 974-9 6 s.

Publikation: Forskning - peer reviewTidsskriftartikel

The aura phase of migraine is associated with focal blood flow changes, but it has been largely unknown whether these changes are correlated to changes in the cerebral metabolism.
Originalsprog Engelsk
Tidsskrift Stroke
Udgivelsesdato maj 1994
Vol/bind 25
Tidsskriftsnummer 5
Sider 974-9
Antal sider 6
ISSN 0039-2499
Status Udgivet

In 92 migraine patients and 44 healthy control subjects we recorded regional cerebral blood flow (rCBF) with single photon emission computerized tomography and (133) Xe inhalation or with i.v. (99m) Tc-HMPAO. Migraine patients were studied interictally. A quantitated analysis of right-left asymmetry indices in a fixed set of regions of interest was compared with the normal asymmetry indices in the healthy controls. An asymmetry index deviating more than ± 2.5 S.D.s in normals was defined as pathological asymmetry. By quantitated analysis 47% of images from patients with aura attacks and 48% of images from patients without aura attacks were established to contain higher rate of asymmetries, the difference being statistically significant (p < 0.05, Wilcoxon). A blinded visual analysis and scoring by a four level scale were done by four experienced observers. rCBF images from 18% of patients having attacks with aura and from 19% of patients without aura attacks was scored as containing abnormal right-left asymmetries by the visual analysis. Images from healthy controls were all scored to be normal. In 37% of the images (all from patients) there was lack of consensus among observers (κ = 0.28). There was no correlation between visual or quantitated abnormalities and age, duration of migraine, frequency of attacks or prophylactic medication. No correlation could be established between asymmetries and the usual side of headache or aura symptoms. Two conclusions emerged: (1) visual evaluation of interictal migraine rCBF images is insufficient to pick up abnormalities; (2) almost 50% of the migraine sufferers had abnormal rCBF/asymmetries. However, these are discrete compared with those typically seen during the aura phase of a migraine attack. One explanation to the patchy rCBF patterns might be that they reflect interictal cerebrovascular dysregulation which might to be a common feature in both types of migraine.

Originalsprog Engelsk
Tidsskrift European journal of neurology : the official journal of the European Federation of Neurological Societies
Udgivelsesdato sep 1994
Vol/bind 1
Tidsskriftsnummer 1
Sider 35-43
Antal sider 9
ISSN 1351-5101
DOI
Status Udgivet

Magnetisk resonans-spektroskopi ved fibromyalgi. En undersøgelse af fosfat-31 spektra fra skeletmuskulaturen i hvile, under og efter arbejde

Jacobsen, S., Jensen, K. E., Thomsen, C., Danneskiold-Samsøe, B. & Henriksen, O. 14 nov. 1994 I : Ugeskrift for laeger. 156, 46, s. 6841-4 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

31phosphorus nuclear magnetic resonance (31P NMR) spectroscopy of painful calf muscle was performed in 12 patients with fibromyalgia and 7 healthy subjects during rest, aerobic and anaerobic exercising conditions, and postexercise recovery. Ratios of inorganic phosphate and creatine phosphate (Pi/PCr) and pH were calculated from the collected 31P NMR spectra. Resting values of Pi/PCr were normal in the patients. Patients only tolerated 49% of the workload tolerated by the controls (P = 0.005). Patients and controls had similar rates of Pi/PCr and pH changes during work and recovery. The controls were able to change their Pi/PCr and pH more than the patients, due to the greater workload reached. However, statistical significance was only reached for the anaerobic static exercise (P = 0.003). It was concluded that fibromyalgia patients have a reduced voluntary capacity for work, but with a biochemical response to work and recovery similar to healthy subjects.
Originalsprog Dansk
Tidsskrift Ugeskrift for laeger
Vol/bind 156
Tidsskriftsnummer 46
Sider (fra-til) 6841-4
Antal sider 4
ISSN 0041-5782
Status Udgivet - 14 nov. 1994

Published in 1993

The primary objectives of this study were to examine to what extent fibromyalgia patients later on developed presumpted causative somatic diseases and to examine symptoms and muscle strength some years after the diagnosis of fibromyalgia was established. A secondary objective was to describe the overlap between fibromyalgia and chronic fatigue syndrome. Only in two of 91 the muscle pain was found to be caused by another somatic disease during the median 4 year follow-up period. In one of the 83 attending subjects a somatic disease associated with muscle symptoms was established at the follow-up visit. 60 out of 83 reported increased pain, 8 reported improvement of pain. The 83 subjects showed no significant fall in muscle strength during the follow-up period. The majority reported severe fatigue but only one fifth fulfilled the proposed chronic fatigue syndrome criteria.
Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rheumatology
Vol/bind 22
Tidsskriftsnummer 1
Sider (fra-til) 35-8
Antal sider 4
ISSN 0300-9742
Status Udgivet - 1993

Bone mass and turnover in fibromyalgia

Jacobsen, S., Gam, A., Egsmose, C., Olsen, M., Danneskiold-Samsøe, B. & Jensen, G. F. maj 1993 I : Journal of Rheumatology. 20, 5, s. 856-9 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Physical inactivity accelerates bone loss. Since patients with fibromyalgia are relatively physically inactive, bone mass and markers of bone metabolism were determined in 12 premenopausal women with fibromyalgia and in healthy age matched female control subjects. No differences were found in lumbar bone mineral density, femoral neck bone mineral density, serum levels of alkaline phosphatase, osteocalcin, ionized calcium and phosphate. The urinary excretion of both hydroxyproline and calcium relative to urinary creatinine excretion was significantly higher in patients with fibromyalgia, p = 0.01. This was linked to lower urinary creatinine excretion (p = 0.02) probably reflecting lower physical activity in the patients with fibromyalgia. We conclude that bone mass and turnover are generally not affected in premenopausal women with fibromyalgia.
Originalsprog Engelsk
Tidsskrift Journal of Rheumatology
Vol/bind 20
Tidsskriftsnummer 5
Sider (fra-til) 856-9
Antal sider 4
ISSN 0315-162X
Status Udgivet - maj 1993

Clinical features in patients with chronic muscle pain--with special reference to fibromyalgia

Jacobsen, S., Petersen, I. S. & Danneskiold-Samsøe, B. 1993 I : Scandinavian Journal of Rheumatology. 22, 2, s. 69-76 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Clinical characteristics were studied in patients with chronic muscle pain, divided into three groups according to the characteristics of their pain; "fibromyalgia" (n = 23), "widespread muscle pain" (n = 21), and "regional muscle pain" (n = 28). Typical fibromyalgia features were also seen in the other groups of patients, but not to the same extent. In particular, sleep disturbance, subjective swelling, cold and exercise intolerance and low self-reported physical performance were significantly related to fibromyalgia. The major components of fibromyalgia were not wholly different compared with other European and North American studies, except for sleep disturbance and subjective swelling, which was somewhat more pronounced in this study. The most used medications in fibromyalgia patients at referral were analgesics, anxiolytic drugs and female sex hormones. Medication in fibromyalgia was not excessive and seemed appropriate compared to the other patient groups. Effects of various biases and classification criteria on the results of fibromyalgia studies are discussed. The characteristic features of fibromyalgia, its stability when diagnosed and the promotion of research and patient management justify the current classification of fibromyalgia at this stage.
Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rheumatology
Vol/bind 22
Tidsskriftsnummer 2
Sider (fra-til) 69-76
Antal sider 8
ISSN 0300-9742
Status Udgivet - 1993

Fibromyalgia in the adult Danish population: I. A prevalence study

Prescott, E., Kjøller, M., Jacobsen, S., Bülow, P. M., Danneskiold-Samsøe, B. & Kamper-Jørgensen, F. 1993 I : Scandinavian Journal of Rheumatology. 22, 5, s. 233-7 5 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Epidemiologic studies of fibromyalgia have so far been based on rheumatologic and general practice settings, which are poor proxies for the underlying population. The study is based on a national health interview survey carried out by the Danish Institute for Clinical Epidemiology in 1990/91 on approx. 6000 randomly selected Danish citizens. For this study 1219 subjects from the eastern part of Denmark aged 18 to 79 years were asked about widespread muscle pain. One-hundred-and-twenty-three persons fulfilled the screening criteria. Clinical examination could be performed on 65 persons (53%). Eight subjects, all female, met the 1990 American College of Rheumatism criteria for fibromyalgia. Dropouts were regarded as not having fibromyalgia. The prevalence of fibromyalgia in the Danish population between 18 and 79 years of age was found to be a minimum estimate of 0.66% (95% confidence limits 0.28%-1.29%).
Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rheumatology
Vol/bind 22
Tidsskriftsnummer 5
Sider (fra-til) 233-7
Antal sider 5
ISSN 0300-9742
Status Udgivet - 1993

Fibromyalgia in the adult Danish population: II. A study of clinical features

Prescott, E., Jacobsen, S., Kjøller, M., Bülow, P. M., Danneskiold-Samsøe, B. & Kamper-Jørgensen, F. 1993 I : Scandinavian Journal of Rheumatology. 22, 5, s. 238-42 5 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Clinical characteristics of fibromyalgia have so far been based mainly on patients identified in rheumatologic settings. This paper offers the clinical findings in fibromyalgia based on a national health interview survey, in which 123 persons fulfilled preset criteria for widespread pain. Clinical examination could be performed on 65 subjects (53%) and included physical examination, tender point palpation by two blinded trained physicians, blood sample analysis, measurement of dynamic muscular strength and a detailed self-administered questionnaire. Significantly more subjective swelling, fatigue, headache, difficulty in stair-climbing, and poorer self-evaluated health with more tender points was found. Contrary to that which was expected, fibromyalgia subjects did not suffer from sleep disturbances, irritable bowels or morning stiffness. Our findings indicate that clinical characteristics of fibromyalgia in the general population may differ from those found in rheumatological settings.
Originalsprog Engelsk
Tidsskrift Scandinavian Journal of Rheumatology
Udgivelsesdato 1993
Vol/bind 22
Tidsskriftsnummer 5
Sider 238-42
Antal sider 5
ISSN 0300-9742
Status Udgivet

Ischaemia-induced (symptomatic) migraine attacks may be more frequent than migraine-induced ischaemic insults

Olesen, J., Friberg, L., Olsen, T. S., Andersen, A. R., Lassen, N. A., Hansen, P. E. & Karle, A. feb 1993 I : Brain. 116 ( Pt 1), s. 187-202 16 s.

Publikation: Forskning - peer reviewTidsskriftartikel

Fifteen consecutive patients with a diagnostic problem of ischaemia-induced migraine with aura (symptomatic migraine) or migraine-associated ischaemia (migrainous infarction) were studied in order to elucidate the mechanisms. Three had a 1 month flurry of daily attacks of migraine auras with or without headache. A severe internal carotid stenosis/occlusion and reduced regional cerebral blood flow (rCBF) was demonstrated. Borderline ischaemia may thus prime the brain for developing migrainous aura with or without migraine (symptomatic migraine). Four patients had a combination of permanent deficits after the very first migraine attack, severe atherosclerosis, risk factors for stroke, high age and no family history of migraine. In these cases the evidence indicates that thromboembolic ischaemia had triggered an attack of migraine with aura (likely symptomatic migraine). Three young females presented long-lasting typical and severe idiopathic migraine with aura. Attack-associated rCBF reduction was likely to have caused permanent, mild, visual or somatosensory deficits (migrainous infarction). In five patients the relationship between migraine and stroke remained unresolved. It seems that ischaemia-induced migraine attacks may be more frequent than migraine-induced ischaemic insults. Therefore, migraine is not as strong a risk factor for stroke as indicated by the mere coincidence of the two disorders.
Originalsprog Engelsk
Tidsskrift Brain
Udgivelsesdato feb 1993
Vol/bind 116 ( Pt 1)
Sider 187-202
Antal sider 16
ISSN 0006-8950
Status Udgivet
The aim was to study the methodological aspects of the muscle twitch interpolation technique in estimating the maximal force of contraction in the quadriceps muscle utilizing commercial muscle testing equipment. Six healthy subjects participated in seven sets of experiments testing the effects on twitch size of potentiation, time lag after potentiation, magnitude of voluntary force, stimulus amplitude, stimulus duration, angle of the knee, and angle of the hip. In addition, the consequences of submaximal potentiation on the estimation of maximal force from twitch sizes were studied in five healthy subjects. We found an increase in twitch size with increasing levels of potentiation and twitch size decreased exponentially following potentiation. We found a curvilinear relationship between twitch size and voluntary force, and these properties were more obvious when the stimulation intensity of the preload was reduced. The relationship between twitch size and force was only linear, for force levels greater than 25% of maximum. It was concluded that to achieve an accurate estimate of true maximal force of muscle contraction, it would be necessary for the subject to be able to perform at least 75% of the true maximal force.
Originalsprog Engelsk
Tidsskrift European Journal of Applied Physiology
Vol/bind 67
Tidsskriftsnummer 5
Sider (fra-til) 462-6
Antal sider 5
ISSN 0301-5548
Status Udgivet - 1993

Published in 1992

31P magnetic resonance spectroscopy of skeletal muscle in patients with fibromyalgia

Jacobsen, S., Jensen, K. E., Thomsen, C., Danneskiold-Samsoe, B. & Henriksen, O. okt. 1992 I : Journal of Rheumatology. 19, 10, s. 1600-1603 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Bidragets oversatte titel 31P magnetic resonance spectroscopy of skeletal muscle in patients with fibromyalgia.
31Phosphorous nuclear magnetic resonance (31P NMR) spectroscopy of painful calf muscle was performed in 12 patients with fibromyalgia (FS) and 7 healthy subjects during rest, aerobic and anaerobic exercising conditions, and postexercise recovery. Ratios of inorganic phosphate and creatinine phosphate (Pi/PCr) and pH were calculated from the collected 31P NMR spectra. Resting values of Pi/PCr were normal in the patients. Patients delivered only 49% of the muscle power of the controls (p = 0.005). Patients and controls had similar rates of Pi/PCr and pH changes during work and recovery. The controls were able to change their Pi/PCr and pH more than the patients, due to the greater workload reached. However, statistical significance was reached only for the anaerobic static exercise (p = 0.003). It was concluded that patients with FS have a reduced voluntary capacity for work, but normal biochemical response to work and recovery.
Originalsprog Engelsk
Tidsskrift Journal of Rheumatology
Vol/bind 19
Tidsskriftsnummer 10
Sider (fra-til) 1600-1603
Antal sider 4
ISSN 0315-162X
Status Udgivet - okt. 1992

Eight stroke patients were examined serially in the acute phase and 1 week and 2-4 weeks after stroke with water-suppressed proton magnetic resonance spectroscopy. The time courses of lactate level and regional cerebral blood flow were studied. A high lactate level was found in the acute phase. The lactate content decreased to barely detectable levels during the following 3 weeks, while regional blood flow increased during this period. The inverse relationship between lactate level and cerebral blood flow suggests that lactate plays no substantial role in the vasodilatation underlying the hyperemia that follows reperfusion. The amount of lactate present in the acute phase reflects the severity of ischemia in the affected region. The lactate level was still above normal in the subacute phase with hyperemia, suggesting lactate production through aerobic glycolysis. Thus, the lactate level in the subacute phase probably does not reflect the degree of anaerobic glycolysis in hypoxic neuronal tissue.

Originalsprog Engelsk
Tidsskrift Journal of Magnetic Resonance Imaging
Udgivelsesdato 1 sep 1992
Vol/bind 2
Tidsskriftsnummer 5
Sider 511-517
Antal sider 7
ISSN 1053-1807
Status Udgivet

Pages