Published in 2012

MRI in Knee Osteoarthritis: Application in diet intervention

Gudbergsen , H. 2012 1 udg. Frederiksberg: Eget Forlag. 69 s.

Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandlingForskning

Originalsprog Engelsk
Udgivelses sted Frederiksberg
Forlag Eget Forlag
Vol/bind 1
Udgave 1
Antal sider 69
Status Udgivet - 2012

Pain and fatigue in chronic noncancer pain patients: How strong is the relationship?

Kendall, S., Holm, NR., Højsted, J., Nielsen, P. R., Jensen, N-H. & Sjøgren, P. 2012

Publikation: KonferencebidragPosterForskningpeer review

Originalsprog Engelsk
Publikationsdato 2012
Status Udgivet - 2012
Begivenhed 14th World Congress on Pain : International Association for the Study of Pain - Milano, Italien
Varighed: 27 aug. 201231 aug. 2012

Konference

Konference 14th World Congress on Pain
Land Italien
By Milano
Periode 27/08/201231/08/2012

Psoriatic arthritis - a follow-up study applying dynamic MRI, conventional MRI and clinical measures

Poggenborg, R. P., Bøyesen, P., Wiell, C., Pedersen, S. J., Sørensen, I. J., Madsen, O. R., Slot, O., Møller, J. M., Boesen, M., Bliddal, H., Kubassova, O. & Østergaard, M. 2012 I : Annals of the Rheumatic Diseases. 71, 3 suppl., s. 711 1 s.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

Originalsprog Engelsk
Tidsskrift Annals of the Rheumatic Diseases
Vol/bind 71
Tidsskriftsnummer 3 suppl.
Sider (fra-til) 711
Antal sider 1
ISSN 0003-4967
Status Udgivet - 2012
Originalsprog Engelsk
Tidsskrift Arthritis & Rheumatism
Vol/bind S451-2
Tidsskriftsnummer 2
Sider (fra-til) S451-2
Antal sider 2
ISSN 0004-3591
Status Udgivet - 2012

Separation of active early rheumatoid arthritis patients and healthy controls by conventional and dynamic contrast-enhanced MRI.

Axelsen, M. B., Ejbjerg, B., Hetland, M. L., Hørslev-Petersen, K., Lauridsen, U. B., Majgaard, O., Boesen, M., Kubassova, O., Bliddal, H. & Østergaard, M. 2012 I : Scandinavian Journal of Rheumatology. Supplement. 41, 126 suppl., s. 28-9 2 s.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

Originalsprog Engelsk
Bogserie Scandinavian Journal of Rheumatology. Supplement
Vol/bind 41
Tidsskriftsnummer 126 suppl.
Sider (fra-til) 28-9
Antal sider 2
ISSN 0301-3847
Status Udgivet - 2012

Statistical principles for prospective study protocols: design, analysis, and reporting

Christensen, R. & Langberg, H. 2012 I : International journal of sports physical therapy. 7, 5, s. 504-11 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

In the design of scientific studies it is essential to decide on which scientific questions one aims to answer, just as it is important to decide on the correct statistical methods to use to answer these questions. The correct use of statistical methods is crucial in all aspects of research to quantify relationships in data. Despite an increased focus on statistical content and complexity of biomedical research these topics remain difficult for most researchers. Statistical methods enable researchers to condense large spreadsheets with data into means, proportions, and difference between means, risk differences, and other quantities that convey information. One of the goals in biomedical research is to develop parsimonious models - meaning as simple as possible. This approach is valid if the subsequent research report (the article) is written independent of whether the results are "statistically significant" or not. In the present paper we outline the considerations and suggestions on how to build a trial protocol, with an emphasis on having a rigorous protocol stage, always leading to a full article manuscript, independent of statistical findings. We conclude that authors, who find (rigorous) protocol writing too troublesome, will realize that they have already written the first half of the final paper if they follow these recommendations; authors simply need to change the protocols future tense into past tense. Thus, the aim of this clinical commentary is to describe and explain the statistical principles for trial protocols in terms of design, analysis, and reporting of findings.
Originalsprog Engelsk
Tidsskrift International journal of sports physical therapy
Vol/bind 7
Tidsskriftsnummer 5
Sider (fra-til) 504-11
Antal sider 8
Status Udgivet - 2012

Stroke and long-term exposure to outdoor air pollution from nitrogen dioxide: a cohort study

Andersen, Z. J., Kristiansen, L. C., Andersen, K. K., Olsen, T. S., Hvidberg, M., Jensen, S. S., Ketzel, M., Loft, S., Sørensen, M., Tjønneland, A., Overvad, K. & Raaschou-Nielsen, O. 2012 I : Stroke. 43, 2, s. 320-5 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Years of exposure to tobacco smoke substantially increase the risk for stroke. Whether long-term exposure to outdoor air pollution can lead to stroke is not yet established. We examined the association between long-term exposure to traffic-related air pollution and incident and fatal stroke in a prospective cohort study.
Originalsprog Engelsk
Tidsskrift Stroke
Vol/bind 43
Tidsskriftsnummer 2
Sider (fra-til) 320-5
Antal sider 6
ISSN 0039-2499
DOI
Status Udgivet - 2012

The iHOT-33: how valid is it?

Thorborg, K., Roos, E. M., Christensen, R., Petersen, J. & Hölmich, P. 2012 I : Arthroscopy: The Journal of Arthroscopy and Related Surgery. 28, 9, s. 1194-5; author reply 1195-6

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Originalsprog Engelsk
Tidsskrift Arthroscopy: The Journal of Arthroscopy and Related Surgery
Vol/bind 28
Tidsskriftsnummer 9
Sider (fra-til) 1194-5; author reply 1195-6
ISSN 0749-8063
DOI
Status Udgivet - 2012
OBJECTIVE: In a cross sectional study, we investigated the relationships between knee pain and mechanical loading across the knee, as indicated by the external knee adduction moment (KAM) during walking in patients with symptomatic knee OA who were distinguished by different radiographic disease severities. METHODS: Data from 137 symptomatic medial knee OA patients were used. Based on Kellgren/Lawrence (K/L) grading, the patients were divided into radiographically less severe (K/L≤2, n=68) or severe (K/L>2, n=69) medial knee OA. Overall knee pain was rated on a 10cm visual analog scale, and peak KAM and KAM impulses were obtained from gait analyses. Mixed linear regression analyses were performed with KAM variables as the outcome, and pain and disease severity as independent variables, adjusting for age, gender, and walking speed. RESULTS: In adjusted analyses, less severe patients demonstrated negative relationships between pain intensities and dynamic loading. The severe patient group showed no relationship between pain intensity and peak KAM, and a positive relationship between pain intensity and KAM impulse. CONCLUSION: In radiographically less severe knee OA, the negative relationships between pain intensity and dynamic knee joint loading indicate a natural reaction to pain, which will limit the stress on the joint. In contrast, either absent or positive relationships between pain and dynamic loading in severe OA may lead to overuse and accelerated disease progression. These findings may have a large potential interest for strategies of treatment in knee OA.
Originalsprog Engelsk
Tidsskrift Knee
Vol/bind 19
Tidsskriftsnummer 4
Sider (fra-til) 392-398
ISSN 0968-0160
DOI
Status Udgivet - 2012

The victorian institute of sports assessment - achilles questionnaire (visa-a) - a reliable tool for measuring achilles tendinopathy

Iversen, J. V., Bartels, E. M. & Langberg, H. 2012 I : International journal of sports physical therapy. 7, 1, s. 76-84 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Achilles tendinopathy (AT) is a common pathology and the aetiology is unknown. For valid and reliable assessment The Victorian Institute of Sports Assessment has designed a self-administered Achilles questionnaire, the VISA-A. The aim of the present study was to evaluate VISA-A as an outcome measure in patients with AT.
Originalsprog Engelsk
Tidsskrift International journal of sports physical therapy
Vol/bind 7
Tidsskriftsnummer 1
Sider (fra-til) 76-84
Antal sider 9
Status Udgivet - 2012

Transdermal opioid patches for pain treatment in ancient Greece

Harrison, A. P., Hansen, S. H. & Bartels, E. M. 2012 I : Pain practice : the official journal of World Institute of Pain. 12, 8, s. 620-5 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Pain treatment in ancient Greece, and through the middle ages in Europe, was to a great extent based on the expertise of the Greek physician Galen (c. 129-200 A.D.). Galen makes particular reference to "Olympic Victor's Dark Ointment" (OVDO), which is listed with a number of collyria. Galen states that OVDO can be useful for treating extreme pain and swellings, forming one of the best eye salves. Olympic Victor's Dark Ointment, an opium-based treatment, forms a "patch" when applied externally as an ointment, because it quickly dries to cover a localized region but still retains its elastic properties. This study has recreated OVDO and applied the ointment to abdominal mouse skin, in vitro. To assess the efficacy of OVDO, the transdermal transfer of morphine was measured when given as OVDO and compared to morphine administered in the form of a solution of Opium + PBS (ringer). Olympic Victor's Dark Ointment showed a transdermal transfer of morphine over time comparable to 25% of the most efficient modern transdermal opioid patches, while hardly any morphine was able to penetrate the skin when applied mixed in PBS. We conclude that OVDO is very efficient in its composition and may carry some forgotten abilities in terms of drug delivery, which could be transferred to modern medicine. Indeed, this may lead to a better choice of morphine use and controlled management in individual patient cases, taking both pain relief and anti-inflammatory aspects into account.
Originalsprog Engelsk
Tidsskrift Pain practice : the official journal of World Institute of Pain
Vol/bind 12
Tidsskriftsnummer 8
Sider (fra-til) 620-5
Antal sider 6
DOI
Status Udgivet - 2012
PURPOSE: MRI is considered the standard of reference for advanced imaging in rheumatoid arthritis (RA). However, in daily clinical practice ultrasound (US) imaging with Doppler information is more versatile and often used for fast and dynamic assessment of joint inflammation. The aim was to compare low-field MRI scores with the US Doppler measurements in the wrist joint of patients with RA. MATERIAL AND METHODS: Fifty consecutive patients with RA (46 women & 4 men) completed both low-field dedicated extremity MRI (E-scan®, Esaote) and a high-end US (Sequioa®, Siemens) imaging of the wrist before initiating either biological treatment (n = 26) or intraarticular injection of Depomedrole® (n = 24). Mean age was 56 years (range 21 - 83 years); mean disease duration 87.2 months (range 4 - 349 months), mean DAS 28 4,8 (range 2 - 7). MRI was scored according to the OMERACT RAMRIS recommendations and US Doppler colour-fractions were determined. RESULTS: Using Spearman's rho, we found a relatively good to moderate correlation between the US colour-fraction and the total OMERACT bone marrow oedema and synovitis scores on MRI (r = 0.6; p 
Originalsprog Engelsk
Tidsskrift Ultraschall in der Medizin
Vol/bind 33
Tidsskriftsnummer 7
Sider (fra-til) E166-E172
ISSN 0172-4614
DOI
Status Udgivet - 2012

Walking on high heels changes muscle activity and the dynamics of human walking significantly

Simonsen, E. B., Svendsen, M. B., Nørreslet, A., Baldvinsson, H. K., Heilskov-Hansen, T., Larsen, P. K., Alkjær, T. & Henriksen, M. 2012 I : Journal of Applied Biomechanics. 28, 1, s. 20-8 9 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The aim of the study was to investigate the distribution of net joint moments in the lower extremities during walking on high-heeled shoes compared with barefooted walking at identical speed. Fourteen female subjects walked at 4 km/h across three force platforms while they were filmed by five digital video cameras operating at 50 frames/second. Both barefooted walking and walking on high-heeled shoes (heel height: 9 cm) were recorded. Net joint moments were calculated by 3D inverse dynamics. EMG was recorded from eight leg muscles. The knee extensor moment peak in the first half of the stance phase was doubled when walking on high heels. The knee joint angle showed that high-heeled walking caused the subjects to flex the knee joint significantly more in the first half of the stance phase. In the frontal plane a significant increase was observed in the knee joint abductor moment and the hip joint abductor moment. Several EMG parameters increased significantly when walking on high-heels. The results indicate a large increase in bone-on-bone forces in the knee joint directly caused by the increased knee joint extensor moment during high-heeled walking, which may explain the observed higher incidence of osteoarthritis in the knee joint in women as compared with men.
Originalsprog Engelsk
Tidsskrift Journal of Applied Biomechanics
Vol/bind 28
Tidsskriftsnummer 1
Sider (fra-til) 20-8
Antal sider 9
ISSN 1065-8483
Status Udgivet - 2012
With an increasing prevalence of older and obese citizens, the problems of knee osteoarthritis (KOA) will escalate. Weight loss is recommended for obese KOA patients and in a majority of cases this leads to symptomatic relief. We hypothesized that pre-treatment structural status of the knee joint, assessed by radiographs, 1.5 T magnetic resonance imaging (MRI) and knee-joint alignment, may influence the symptomatic changes following a significant weight reduction.
Originalsprog Engelsk
Tidsskrift Osteoarthritis and Cartilage
Vol/bind 20
Tidsskriftsnummer 6
Sider (fra-til) 495-502
Antal sider 8
ISSN 1063-4584
DOI
Status Udgivet - 2012

Published in 2011

A 60-year-old obese woman with osteoarthritis of the knee: a case-report.

Christensen, P., Riecke, B. F., Christensen, R. D. K. & Bliddal, H. 2011 I : Clinical Obesity. 1, 1, s. 53 56 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Originalsprog Engelsk
Tidsskrift Clinical Obesity
Vol/bind 1
Tidsskriftsnummer 1
Sider (fra-til) 53
Antal sider 56
Status Udgivet - 2011
Originalsprog Engelsk
Tidsskrift Results in Pharma Sciences
Vol/bind 1
Sider (fra-til) 76
Antal sider 79
ISSN 2211-2863
Status Udgivet - 2011

Abatacept with methotrexate versus other biologic agents in treatment of patients with active rheumatoid arthritis despite methotrexate: a network meta-analysis

Guyot, P., Taylor, P., Christensen, R., Pericleous, L., Poncet, C., Lebmeier, M., Drost, P. & Bergman, G. 2011 I : Arthritis Research & Therapy. 13, 6, s. R204

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The goal of this study was to compare the efficacy in terms of Health Assessment Questionnaire change from baseline (HAQ CFB), 50% improvement in American College of Rheumatology criterion (ACR-50) and Disease Activity Score in 28 joints (DAS28) defined remission (<2.6) between abatacept and other biologic disease modifying anti-rheumatic drugs (DMARDs) in patients with rheumatoid arthritis (RA) who have inadequate response to methotrexate (MTX-IR).
Originalsprog Engelsk
Tidsskrift Arthritis Research & Therapy
Vol/bind 13
Tidsskriftsnummer 6
Sider (fra-til) R204
ISSN 1478-6354
DOI
Status Udgivet - 2011

Adaptations in the gait pattern with experimental hamstring pain

Henriksen, M., Mortensen, S. R., Aaboe, J. & Bliddal, H. 6 aug. 2011 I : Journal of Electromyography & Kinesiology. 21, 5, s. 746-753

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Pain changes movement but most studies have focused on basic physiological adaptations during non-functional movement tasks. The existing studies on how pain affects lower extremity gross movement biomechanics have primarily involved movements in which the quadriceps is the primary muscle and little attention has been given to how pain in other muscles affects functional movement. The purpose of this study was to investigate the changes in the gait patterns of healthy subjects that occur during experimental muscle pain in the biceps femoris. In a cross-over study design, 14 healthy volunteers underwent EMG assisted 3D gait analyses before, during and after experimental biceps femoris pain induced by intramuscular injections of hypertonic saline. Isotonic saline injections were administered as a non-painful control. The experimental biceps femoris pain led to reductions in hip extensor moments, knee flexor and lateral rotator moments. No changes in lower extremity kinematics and EMG activity in any of the recorded muscles were observed. It is concluded that experimental muscle pain in the biceps femoris leads to changes in the gait pattern in agreement with unloading of the painful muscle. The changes are specific to the painful muscle. The present study provides support to the theory that musculoskeletal pain is a protective signal leading to changes in movement patterns that serve to unload the painful tissue.
Originalsprog Engelsk
Tidsskrift Journal of Electromyography & Kinesiology
Vol/bind 21
Tidsskriftsnummer 5
Sider (fra-til) 746-753
ISSN 1050-6411
DOI
Status Udgivet - 6 aug. 2011

Adverse effects of biologics: a network meta-analysis and Cochrane overview

Singh, J. A., Wells, G. A., Christensen, R., Tanjong Ghogomu, E., Maxwell, L., Macdonald, J. K., Filippini, G., Skoetz, N., Francis, D., Lopes, L. C., Guyatt, G. H., Schmitt, J., La Mantia, L., Weberschock, T., Roos, J. F., Siebert, H., Hershan, S., Lunn, M. P., Tugwell, P. & Buchbinder, R. 1 jan. 2011 I : Cochrane Database of Systematic Reviews. 2, s. CD008794

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Biologics are used for the treatment of rheumatoid arthritis and many other conditions. While the efficacy of biologics has been established, there is uncertainty regarding the adverse effects of this treatment. Since serious risks such as tuberculosis (TB) reactivation, serious infections, and lymphomas may be common to the biologics but occur in small numbers across the various indications, we planned to combine the results from biologics used in many conditions to obtain the much needed risk estimates.
Originalsprog Engelsk
Tidsskrift Cochrane Database of Systematic Reviews
Tidsskriftsnummer 2
Sider (fra-til) CD008794
ISSN 1469-493X
DOI
Status Udgivet - 1 jan. 2011

Age trajectories of stroke case fatality: leveling off at the highest ages

Olsen, T. S., Andersen, Z. J. & Andersen, K. K. 2011 I : Epidemiology. 22, 3, s. 432-6 5 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Mortality rates level off at older ages. Age trajectories of stroke case-fatality rates were studied with the aim of investigating prevalence of this phenomenon, specifically in case-fatality rates at older ages.
Originalsprog Engelsk
Tidsskrift Epidemiology
Vol/bind 22
Tidsskriftsnummer 3
Sider (fra-til) 432-6
Antal sider 5
ISSN 1044-3983
DOI
Status Udgivet - 2011

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