Published in 2012

With an increasing prevalence of older and obese citizens, the problems of knee osteoarthritis (KOA) will escalate. Weight loss is recommended for obese KOA patients and in a majority of cases this leads to symptomatic relief. We hypothesized that pre-treatment structural status of the knee joint, assessed by radiographs, 1.5 T magnetic resonance imaging (MRI) and knee-joint alignment, may influence the symptomatic changes following a significant weight reduction.
Originalsprog Engelsk
Tidsskrift Osteoarthritis and Cartilage
Vol/bind 20
Tidsskriftsnummer 6
Sider (fra-til) 495-502
Antal sider 8
ISSN 1063-4584
DOI
Status Udgivet - 2012

Published in 2011

A 60-year-old obese woman with osteoarthritis of the knee: a case-report.

Christensen, P., Riecke, B. F., Christensen, R. D. K. & Bliddal, H. 2011 I : Clinical Obesity. 1, 1, s. 53 56 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Originalsprog Engelsk
Tidsskrift Clinical Obesity
Vol/bind 1
Tidsskriftsnummer 1
Sider (fra-til) 53
Antal sider 56
Status Udgivet - 2011
Originalsprog Engelsk
Tidsskrift Results in Pharma Sciences
Vol/bind 1
Sider (fra-til) 76
Antal sider 79
ISSN 2211-2863
Status Udgivet - 2011

Abatacept with methotrexate versus other biologic agents in treatment of patients with active rheumatoid arthritis despite methotrexate: a network meta-analysis

Guyot, P., Taylor, P., Christensen, R., Pericleous, L., Poncet, C., Lebmeier, M., Drost, P. & Bergman, G. 2011 I : Arthritis Research & Therapy. 13, 6, s. R204

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The goal of this study was to compare the efficacy in terms of Health Assessment Questionnaire change from baseline (HAQ CFB), 50% improvement in American College of Rheumatology criterion (ACR-50) and Disease Activity Score in 28 joints (DAS28) defined remission (<2.6) between abatacept and other biologic disease modifying anti-rheumatic drugs (DMARDs) in patients with rheumatoid arthritis (RA) who have inadequate response to methotrexate (MTX-IR).
Originalsprog Engelsk
Tidsskrift Arthritis Research & Therapy
Vol/bind 13
Tidsskriftsnummer 6
Sider (fra-til) R204
ISSN 1478-6354
DOI
Status Udgivet - 2011

Adaptations in the gait pattern with experimental hamstring pain

Henriksen, M., Mortensen, S. R., Aaboe, J. & Bliddal, H. 6 aug. 2011 I : Journal of Electromyography & Kinesiology. 21, 5, s. 746-753

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Pain changes movement but most studies have focused on basic physiological adaptations during non-functional movement tasks. The existing studies on how pain affects lower extremity gross movement biomechanics have primarily involved movements in which the quadriceps is the primary muscle and little attention has been given to how pain in other muscles affects functional movement. The purpose of this study was to investigate the changes in the gait patterns of healthy subjects that occur during experimental muscle pain in the biceps femoris. In a cross-over study design, 14 healthy volunteers underwent EMG assisted 3D gait analyses before, during and after experimental biceps femoris pain induced by intramuscular injections of hypertonic saline. Isotonic saline injections were administered as a non-painful control. The experimental biceps femoris pain led to reductions in hip extensor moments, knee flexor and lateral rotator moments. No changes in lower extremity kinematics and EMG activity in any of the recorded muscles were observed. It is concluded that experimental muscle pain in the biceps femoris leads to changes in the gait pattern in agreement with unloading of the painful muscle. The changes are specific to the painful muscle. The present study provides support to the theory that musculoskeletal pain is a protective signal leading to changes in movement patterns that serve to unload the painful tissue.
Originalsprog Engelsk
Tidsskrift Journal of Electromyography & Kinesiology
Vol/bind 21
Tidsskriftsnummer 5
Sider (fra-til) 746-753
ISSN 1050-6411
DOI
Status Udgivet - 6 aug. 2011

Adverse effects of biologics: a network meta-analysis and Cochrane overview

Singh, J. A., Wells, G. A., Christensen, R., Tanjong Ghogomu, E., Maxwell, L., Macdonald, J. K., Filippini, G., Skoetz, N., Francis, D., Lopes, L. C., Guyatt, G. H., Schmitt, J., La Mantia, L., Weberschock, T., Roos, J. F., Siebert, H., Hershan, S., Lunn, M. P., Tugwell, P. & Buchbinder, R. 1 jan. 2011 I : Cochrane Database of Systematic Reviews. 2, s. CD008794

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Biologics are used for the treatment of rheumatoid arthritis and many other conditions. While the efficacy of biologics has been established, there is uncertainty regarding the adverse effects of this treatment. Since serious risks such as tuberculosis (TB) reactivation, serious infections, and lymphomas may be common to the biologics but occur in small numbers across the various indications, we planned to combine the results from biologics used in many conditions to obtain the much needed risk estimates.
Originalsprog Engelsk
Tidsskrift Cochrane Database of Systematic Reviews
Tidsskriftsnummer 2
Sider (fra-til) CD008794
ISSN 1469-493X
DOI
Status Udgivet - 1 jan. 2011

Age trajectories of stroke case fatality: leveling off at the highest ages

Olsen, T. S., Andersen, Z. J. & Andersen, K. K. 2011 I : Epidemiology. 22, 3, s. 432-6 5 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Mortality rates level off at older ages. Age trajectories of stroke case-fatality rates were studied with the aim of investigating prevalence of this phenomenon, specifically in case-fatality rates at older ages.
Originalsprog Engelsk
Tidsskrift Epidemiology
Vol/bind 22
Tidsskriftsnummer 3
Sider (fra-til) 432-6
Antal sider 5
ISSN 1044-3983
DOI
Status Udgivet - 2011

An international, randomized, double-blind, placebo-controlled, phase III trial of pregabalin monotherapy in treatment of patients with fibromyalgia

Pauer, L., Winkelmann, A., Arsenault, P., Jespersen, A., Whelan, L., Atkinson, G., Leon, T., Zeiher, B. & A0081100 Investigators 2011 I : Journal of Rheumatology. 38, 12, s. 2643-52 10 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

To evaluate the efficacy and safety of pregabalin monotherapy versus placebo for symptomatic pain relief and improvement of patient global assessment in patients with fibromyalgia (FM) enrolled from countries outside the United States.
Originalsprog Engelsk
Tidsskrift Journal of Rheumatology
Vol/bind 38
Tidsskriftsnummer 12
Sider (fra-til) 2643-52
Antal sider 10
ISSN 0315-162X
DOI
Status Udgivet - 2011

Andre reumatiske sygdomme

Bliddal, H. 2011 Klinisk Reumatologi. Danneskiold-Samsøe, B., Lund, H. & Währens, E. E. (red.). 2 udg. København: Munksgård Danmark, Bind 1, s. 199-206 8 s.

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiFormidling

Originalsprog Dansk
Titel Klinisk Reumatologi
Redaktører Bente Danneskiold-Samsøe, Hans Lund, Eva Ejlersen Währens
Antal sider 8
Vol/bind 1
Udgivelses sted København
Forlag Munksgård Danmark
Publikationsdato 2011
Udgave 2
Sider 199-206
???Chapter??? 14
ISBN (Trykt) 9788762806726
Status Udgivet - 2011
Theoretically, the high spatial resolution of US makes it well suited to monitor the decrease in articular cartilage thickness in osteoarthritis. A requirement is, however, that the borders of the cartilage are correctly identified and that the cartilage is measured under orthogonal insonation. If US measurements are compared to measurements with other techniques, they should be corrected for the higher sound speed in cartilage.
Originalsprog Engelsk
Tidsskrift Ultraschall in der Medizin
Vol/bind 32
Tidsskriftsnummer 1
Sider (fra-til) 54-61
Antal sider 8
ISSN 0172-4614
DOI
Status Udgivet - 2011

Bevægeapparatets biomekanik i relation til muskel- og skeletsygdomme

Henriksen, M. & Bojsen-Møller, F. 2011 Klinisk Reumatologi. Danneskiold-Samsøe, B., Lund, H. & Währens, E. E. (red.). 2 udg. København: Munksgård Danmark, Bind 1, s. 55-69 15 s.

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiFormidling

Originalsprog Dansk
Titel Klinisk Reumatologi
Redaktører Bente Danneskiold-Samsøe, Hans Lund, Eva ejlersen Währens
Antal sider 15
Vol/bind 1
Udgivelses sted København
Forlag Munksgård Danmark
Publikationsdato 2011
Udgave 2
Sider 55-69
???Chapter??? 5
ISBN (Trykt) 9788762806726
Status Udgivet - 2011

Biomechanical Adaptations to Body Weight - Implications for Knee Osteoarthritis Patients

Aaboe, J. 2011 København: Eget forlag.

Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandlingForskning

Originalsprog Engelsk
Forlag København: Eget forlag
Status Udgivet - 2011

Borgerinddragelse - borgersamarbejde

Schriver, N. B., Bartels, E. M. & Pind, D. 2011 Klinisk Reumatologi. Danneskiold-Samsøe, B., Lund, H. & Währens, E. E. (red.). 2 udg. København: Munksgård Danmark, Bind 1, s. 383-392 10 s.

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiFormidling

Originalsprog Dansk
Titel Klinisk Reumatologi
Redaktører Bente Danneskiold-Samsøe, Hans Lund, Eva Ejlersen Währens
Antal sider 10
Vol/bind 1
Udgivelses sted København
Forlag Munksgård Danmark
Publikationsdato 2011
Udgave 2
Sider 383-392
???Chapter??? 25
ISBN (Trykt) 9788762806726
Status Udgivet - 2011

Calcium-dependence of Donnan potentials in glycerinated rabbit psoas muscle in rigor, at and beyond filament overlap; a role for titin in the contractile process

Coomber, S. J., Bartels, E. M. & Elliott, G. F. 2011 I : Cell Calcium. 50, 1, s. 91-7 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

In glycerinated rabbit psoas muscle, Donnan potential measurements demonstrated that the net electric charge on the actin-myosin matrix undergoes a sharp switch-like transition at pCa(50) = 6.8. The potentials are 2 mV less negative at the lower pCa(2+) (P <0.001). If ATP is present, the muscle contracts and breaks the microelectrode. Therefore the rigor state was studied. There is no reason to suppose a priori that a similar voltage switch does not occur during contraction, however. Calcium dependence is still apparent in muscles stretched beyond overlap (sarcomere length>3.8 μm) and is also seen in the gap filaments between the A- and I-band ends; further stretching abolishes the dependence. These experiments strongly suggest that calcium dependence is controlled initially by the titin component, and that this control is lost when titin filaments break. We suppose that that effect is mediated by the titin kinase in the M-line region and may involve the extensible PEVK region of titin. There is great interest in the electric charge on proteins in muscle within the structural system. We suggest how changes in these charges may control the calcium activation process. We also suggest some simple experimental approaches that could clarify these effects.
Originalsprog Engelsk
Tidsskrift Cell Calcium
Vol/bind 50
Tidsskriftsnummer 1
Sider (fra-til) 91-7
Antal sider 7
ISSN 0143-4160
DOI
Status Udgivet - 2011

Characterization by biopsy or CEUS of liver lesions guided by image fusion between ultrasonography and CT, PET/CT or MRI

Ewertsen, C., Henriksen, B. M., Torp-Pedersen, S. & Bachmann Nielsen, M. 2011 I : Ultraschall in der Medizin. 32, 2, s. 191-7 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

The aim of this study was to show the number of cases in which the use of fusion-guided ultrasonography (US) provided conclusive diagnosis of lesions in the liver seen on CT or MRI or PET/CT. A lesion is defined as a region that has suffered damage due to injury or disease.
Originalsprog Engelsk
Tidsskrift Ultraschall in der Medizin
Vol/bind 32
Tidsskriftsnummer 2
Sider (fra-til) 191-7
Antal sider 7
ISSN 0172-4614
DOI
Status Udgivet - 2011

Comparison of a low-energy diet and a very low-energy diet in sedentary obese individuals: a pragmatic randomized controlled trial.

Christensen, P., Bliddal, H., Riecke, B. F., AR, L., Astrup, A. V. & Christensen, R. D. K. 2011 I : Clinical Obesity. 1, s. 31 40 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Originalsprog Engelsk
Tidsskrift Clinical Obesity
Vol/bind 1
Sider (fra-til) 31
Antal sider 40
Status Udgivet - 2011

Comparison of the manual and computer-aided techniques for evaluation of wrist synovitis using dynamic contrast-enhanced MRI on a dedicated scanner

Boesen, M., Kubassova, O., Parodi, M., Bliddal, H., Innocenti, S., Garlaschi, G. & Cimmino, M. A. 2011 I : European Journal of Radiology. 77, 2, s. 202-6 5 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Traditional methods for assessment of synovial inflammation in rheumatoid arthritis such as clinical examination, immunohistology of bioptic samples, scintigraphy, and radiography have several limitations, including lack of sensitivity, need of invasive techniques, and administration of radioactive material. MRI lacks on standardisation and the data are often analysed using laborious, relatively rigid scoring methods.
Originalsprog Engelsk
Tidsskrift European Journal of Radiology
Vol/bind 77
Tidsskriftsnummer 2
Sider (fra-til) 202-6
Antal sider 5
ISSN 0720-048X
DOI
Status Udgivet - 2011
Originalsprog Engelsk
Tidsskrift Annals of the Rheumatic Diseases
Vol/bind 70
Tidsskriftsnummer (Suppl. 3)
Sider (fra-til) 548-549
Antal sider 2
ISSN 0003-4967
Status Udgivet - 2011

Construct validity and responsiveness of dynamic contrast-enhanced magnetic resonance imaging in early rheumatoid arthritis - A comparison with conventional magnetic resonance imaging and clinical measures of disease activity.

Axelsen, M. B., Ejbjerg, B. J., Hetland, M. L., Hørslev-Petersen, K., Boesen, M., Kubassova, O., Lauridsen, U. B., Majgaard, O., Bliddal, H., Krogh, N. S. & Østergaard, M. 2011 I : Arthritis & Rheumatism. 63, 10 (Suppl.), s. S370-S371 2 s.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

Originalsprog Engelsk
Tidsskrift Arthritis & Rheumatism
Vol/bind 63
Tidsskriftsnummer 10 (Suppl.)
Sider (fra-til) S370-S371
Antal sider 2
ISSN 0004-3591
Status Udgivet - 2011
The aim of this systematic review and meta-analysis was to summarize the evidence from observational studies assessing the association between intake of trans fatty acids (TFA) and the risk of coronary heart disease (CHD), with a specific emphasis on distinguishing between TFA of industrial and ruminant origin. By searching five bibliographic databases, analyses from six published and two unpublished prospective cohort studies, assessing the association of intake of TFA with fatal and/or non-fatal CHD, were identified. Four and three studies reported separate associations for intake of ruminant or industrial-TFA, respectively. The pooled relative risk estimates for comparison of extreme quintiles of total-TFA intake (corresponding to intake increments ranging from 2.8 to ∼10 g/day) were 1.22 (95% confidence interval: 1.08-1.38; P=0.002) for CHD events and 1.24 (1.07-1.43; P=0.003) for fatal CHD. Ruminant-TFA intake (increments ranging from 0.5 to 1.9 g/day) was not significantly associated with risk of CHD (risk ratio (RR)=0.92 (0.76-1.11); P=0.36), and neither was industrial-TFA intake, although there was a trend towards a positive association (RR=1.21 (0.97-1.50); P=0.09). In conclusion, our analysis suggests that industrial-TFA may be positively related to CHD, whereas ruminant-TFA is not, but the limited number of available studies prohibits any firm conclusions concerning whether the source of TFA is important. The null association of ruminant-TFA with CHD risk may be due to lower intake levels.
Originalsprog Engelsk
Tidsskrift European Journal of Clinical Nutrition
Vol/bind 65
Tidsskriftsnummer 7
Sider (fra-til) 773-83
Antal sider 11
ISSN 0954-3007
DOI
Status Udgivet - 1 jul. 2011

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