Published in 2013

Experimental knee pain evoke spreading hyperalgesia and facilitated temporal summation of pain

Joergensen, T. S., Henriksen, M., Danneskiold-Samsoee, B., Bliddal, H. & Graven-Nielsen, T. jun. 2013 I : Pain medicine (Malden, Mass.). 14, 6, s. 874-83 10 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

OBJECTIVES: This study evaluated the deep-tissue pressure pain sensitivity and temporal summation of pain within and around healthy knees exposed to experimental pain.

DESIGN: The study was designed as a randomized crossover trial, with each subject tested on 1 day.

SETTING: All tests were carried out at the Laboratory for Musculoskeletal Pain and Motor Control, Center for Sensory-Motor Interaction, Department of Health Science and Technology at Aalborg University, Denmark.

SUBJECTS: Seventeen healthy subjects (10 males) participated in this study.

INTERVENTIONS: Experimental pain model. Pain was induced in the infrapatellar fat pad by injection of hypertonic saline and the contralateral infrapatellar fat pad was injected with isotonic saline as control.

OUTCOME MEASURES: Pressure pain thresholds, temporal summation of pressure pain, and cutaneous mechanosensitivity were assessed on three occasions: baseline, immediately after the injection, and when pain had vanished. Assessments sites were located in the peripatellar region, vastus lateralis, and tibialis anterior muscles.

RESULTS: The experimental knee pain model demonstrated 1) hyperalgesia to pressure stimulation on the infrapatellar fat pad during experimental pain, and 2) facilitated temporal summation of pressure pain at the infrapatellar fat pad and knee-related muscles.

CONCLUSION: The increased sensitivity and temporal summation found in this study were exclusive to deep -tissue with no contralateral decreased pain sensitivity. The study showed that acute knee joint pain leads to hyperalgesia and facilitated temporal summation in the infrapatellar fat pad and in muscles located distant to the injection site, in subjects with no history of knee pain.

Originalsprog Engelsk
Tidsskrift Pain medicine (Malden, Mass.)
Vol/bind 14
Tidsskriftsnummer 6
Sider (fra-til) 874-83
Antal sider 10
ISSN 1526-2375
DOI
Status Udgivet - jun. 2013

External pneumatic compression device prevents fainting in standing weight-bearing MRI: a cohort study

Hansen, B. B., Bouert, R., Bliddal, H., Christensen, R., Bendix, T., Christensen, A., Mehlsen, J., Rasti, Z. & Boesen, M. okt. 2013 I : Skeletal Radiology. 42, 10, s. 1437-42 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

To investigate if a peristaltic external pneumatic compression device attached to the legs, while scanning, can reduce a substantial risk of fainting in standing weight-bearing magnetic resonance imaging (MRI).
Originalsprog Engelsk
Tidsskrift Skeletal Radiology
Vol/bind 42
Tidsskriftsnummer 10
Sider (fra-til) 1437-42
Antal sider 6
ISSN 0364-2348
DOI
Status Udgivet - okt. 2013

GRADE guidelines: 12. Preparing summary of findings tables-binary outcomes

Guyatt, G. H., Oxman, A. D., Santesso, N., Helfand, M., Vist, G., Kunz, R., Brozek, J., Norris, S., Meerpohl, J., Djulbegovic, B., Alonso-Coello, P., Post, P. N., Busse, J. W., Glasziou, P., Christensen, R. & Schünemann, H. J. feb. 2013 I : Journal of Clinical Epidemiology. 66, 2, s. 158-72 15 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Summary of Findings (SoF) tables present, for each of the seven (or fewer) most important outcomes, the following: the number of studies and number of participants; the confidence in effect estimates (quality of evidence); and the best estimates of relative and absolute effects. Potentially challenging choices in preparing SoF table include using direct evidence (which may have very few events) or indirect evidence (from a surrogate) as the best evidence for a treatment effect. If a surrogate is chosen, it must be labeled as substituting for the corresponding patient-important outcome. Another such choice is presenting evidence from low-quality randomized trials or high-quality observational studies. When in doubt, a reasonable approach is to present both sets of evidence; if the two bodies of evidence have similar quality but discrepant results, one would rate down further for inconsistency. For binary outcomes, relative risks (RRs) are the preferred measure of relative effect and, in most instances, are applied to the baseline or control group risks to generate absolute risks. Ideally, the baseline risks come from observational studies including representative patients and identifying easily measured prognostic factors that define groups at differing risk. In the absence of such studies, relevant randomized trials provide estimates of baseline risk. When confidence intervals (CIs) around the relative effect include no difference, one may simply state in the absolute risk column that results fail to show a difference, omit the point estimate and report only the CIs, or add a comment emphasizing the uncertainty associated with the point estimate.
Originalsprog Engelsk
Tidsskrift Journal of Clinical Epidemiology
Vol/bind 66
Tidsskriftsnummer 2
Sider (fra-til) 158-72
Antal sider 15
ISSN 0895-4356
DOI
Status Udgivet - feb. 2013

GRADE guidelines: 13. Preparing summary of findings tables and evidence profiles-continuous outcomes

Guyatt, G. H., Thorlund, K., Oxman, A. D., Walter, S. D., Patrick, D., Furukawa, T. A., Johnston, B. C., Karanicolas, P., Akl, E. A., Vist, G., Kunz, R., Brozek, J., Kupper, L. L., Martin, S. L., Meerpohl, J. J., Alonso-Coello, P., Christensen, R. & Schunemann, H. J. feb. 2013 I : Journal of Clinical Epidemiology. 66, 2, s. 173-83 11 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Presenting continuous outcomes in Summary of Findings tables presents particular challenges to interpretation. When each study uses the same outcome measure, and the units of that measure are intuitively interpretable (e.g., duration of hospitalization, duration of symptoms), presenting differences in means is usually desirable. When the natural units of the outcome measure are not easily interpretable, choosing a threshold to create a binary outcome and presenting relative and absolute effects become a more attractive alternative. When studies use different measures of the same construct, calculating summary measures requires converting to the same units of measurement for each study. The longest standing and most widely used approach is to divide the difference in means in each study by its standard deviation and present pooled results in standard deviation units (standardized mean difference). Disadvantages of this approach include vulnerability to varying degrees of heterogeneity in the underlying populations and difficulties in interpretation. Alternatives include presenting results in the units of the most popular or interpretable measure, converting to dichotomous measures and presenting relative and absolute effects, presenting the ratio of the means of intervention and control groups, and presenting the results in minimally important difference units. We outline the merits and limitations of each alternative and provide guidance for meta-analysts and guideline developers.
Originalsprog Engelsk
Tidsskrift Journal of Clinical Epidemiology
Vol/bind 66
Tidsskriftsnummer 2
Sider (fra-til) 173-83
Antal sider 11
ISSN 0895-4356
DOI
Status Udgivet - feb. 2013

How to perform a systematic search

Bartels, E. M. apr. 2013 I : Best Practice & Research: Clinical Rheumatology. 27, 2, s. 295-306 12 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

All medical practice and research must be evidence-based, as far as this is possible. With medical knowledge constantly growing, it has become necessary to possess a high level of information literacy to stay competent and professional. Furthermore, as patients can now search information on the Internet, clinicians must be able to respond to this type of information in a professional way, when needed. Here, the development of viable systematic search strategies for journal articles, books, book chapters and other sources, selection of appropriate databases, search tools and selection methods are described and illustrated with examples from rheumatology. The up-keep of skills over time, and the acquisition of localised information sources, are discussed.
Originalsprog Engelsk
Tidsskrift Best Practice & Research: Clinical Rheumatology
Vol/bind 27
Tidsskriftsnummer 2
Sider (fra-til) 295-306
Antal sider 12
ISSN 1521-6942
DOI
Status Udgivet - apr. 2013

Imaging in juvenile idiopathic arthritis with a focus on ultrasonography

Laurell, L., Court-Payen, M., Boesen, M. & Fasth, A. 2013 I : Clinical and Experimental Rheumatology. 31, 1, s. 135-48 14 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Early therapeutic intervention and use of new highly efficacious treatments have improved the outcome in many patients with juvenile idiopathic arthritis (JIA), but have also led to the need for more precise methods to evaluate disease activity. In adult rheumatology, numerous studies have established the importance of magnetic resonance imaging (MRI) and ultrasonography (US), and MRI is considered the reference standard. Nevertheless, due to differences in disease characteristics and the unique features of the growing skeleton, the findings obtained in adults are not directly applicable to children and adolescents. For paediatric patients, US offers specific advantages over MRI, because it is non-invasive, does not require sedation or general anesthesia (which facilitates repeated examinations for follow-up), is quickly accessible bedside, and is easy to combine with clinical assessment (interactivity). Agitation of the patient is rarely a problem, and hence young children can be seated on a parent's lap or play while being examined, and multiple locations can be assessed during a single session. Furthermore, modern high-frequency US transducers used by experienced US examiners can provide unsurpassed resolution of the superficial musculoskeletal structures in children. US is also the best available technique for imaging guidance of steroid injections. Unfortunately, there are still no validated MRI or US scoring systems for evaluating inflammatory and joint damage abnormalities in JIA, and few US studies have been conducted. Sonographic assessment of disease activity has, however, been proven to be more informative than clinical examination and is also readily available at points of care. This review summarises the literature on imaging in JIA, focusing on US and the important role this technique will play in JIA in the future.
Originalsprog Engelsk
Tidsskrift Clinical and Experimental Rheumatology
Vol/bind 31
Tidsskriftsnummer 1
Sider (fra-til) 135-48
Antal sider 14
ISSN 0392-856X
Status Udgivet - 2013

Impact of tumour necrosis factor inhibitor treatment on radiographic progression in rheumatoid arthritis patients in clinical practice: results from the nationwide Danish DANBIO registry

Ørnbjerg, L. M., Østergaard, M., Bøyesen, P., Krogh, N. S., Thormann, A., Tarp, U., Poulsen, U. E., Espesen, J., Ringsdal, V. S., Graudal, N., Kollerup, G. B., Jensen, D. V., Madsen, O. R., Glintborg, B., Christensen, T. S., Lindegaard, H. M., Dencker, D., Hansen, A., Andersen, A. R. & Hetland, M. L. 2013 I : Annals of the Rheumatic Diseases. 72, 1, s. 57-63 7 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

To compare radiographic progression during treatment with disease-modifying antirheumatic drugs (DMARD) and subsequent treatment with tumour necrosis factor α inhibitors (TNF-I) in rheumatoid arthritis (RA) patients in clinical practice.
Originalsprog Engelsk
Tidsskrift Annals of the Rheumatic Diseases
Vol/bind 72
Tidsskriftsnummer 1
Sider (fra-til) 57-63
Antal sider 7
ISSN 0003-4967
DOI
Status Udgivet - 2013

Incidences of overall and site specific cancers in TNFα inhibitor treated patients with rheumatoid arthritis and other arthritides - a follow-up study from the DANBIO Registry

Dreyer, L., Mellemkjær, L., Andersen, A. R., Bennett, P., Poulsen, U. E., Juulsgaard Ellingsen, T., Hansen, T. H., Jensen, D. V., Linde, L., Lindegaard, H. M., Loft, A. G. R., Nordin, H., Omerovic, E., Rasmussen, C., Schlemmer, A., Tarp, U. & Hetland, M. L. 2013 I : Annals of the Rheumatic Diseases. 72, 1, s. 79-82 4 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

To investigate the incidence of cancer in arthritis patients treated with or without TNFα inhibitors (TNF-I).
Originalsprog Engelsk
Tidsskrift Annals of the Rheumatic Diseases
Vol/bind 72
Tidsskriftsnummer 1
Sider (fra-til) 79-82
Antal sider 4
ISSN 0003-4967
DOI
Status Udgivet - 2013

Internal strain estimation for quantification of human heel pad elastic modulus: A phantom study

Holst, K., Liebgott, H., Wilhjelm, J. E., Nikolov, S., Torp-Pedersen, S. T., Delachartre, P. & Jensen, J. A. feb. 2013 I : Ultrasonics. 53, 2, s. 439-46 8 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Shock absorption is the most important function of the human heel pad. However, changes in heel pad elasticity, as seen in e.g. long-distance runners, diabetes patients, and victims of Falanga torture are affecting this function, often in a painful manner. Assessment of heel pad elasticity is usually based on one or a few strain measurements obtained by an external load-deformation system. The aim of this study was to develop a technique for quantitative measurements of heel pad elastic modulus based on several internal strain measures from within the heel pad by use of ultrasound images. Nine heel phantoms were manufactured featuring a combination of three heel pad stiffnesses and three heel pad thicknesses to model the normal human variation. Each phantom was tested in an indentation system comprising a 7MHz linear array ultrasound transducer, working as the indentor, and a connected load cell. Load-compression data and ultrasound B-mode images were simultaneously acquired in 19 compression steps of 0.1mm each. The internal tissue displacement was for each step calculated by a phase-based cross-correlation technique and internal strain maps were derived from these displacement maps. Elastic moduli were found from the resulting stress-strain curves. The elastic moduli made it possible to distinguish eight of nine phantoms from each other according to the manufactured stiffness and showed very little dependence of the thickness. Mean elastic moduli for the three soft, the three medium, and the three hard phantoms were 89kPa, 153kPa, and 168kPa, respectively. The combination of ultrasound images and force measurements provided an effective way of assessing the elastic properties of the heel pad due to the internal strain estimation.
Originalsprog Engelsk
Tidsskrift Ultrasonics
Vol/bind 53
Tidsskriftsnummer 2
Sider (fra-til) 439-46
Antal sider 8
ISSN 0041-624X
DOI
Status Udgivet - feb. 2013

Is beer consumption related to measures of abdominal and general obesity? A systematic review and meta-analysis

Bendsen, N. T., Christensen, R., Bartels, E. M., Kok, F. J., Sierksma, A., Raben, A. B. & Astrup, A. feb. 2013 I : Nutrition Reviews. 71, 2, s. 67-87 21 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

A systematic review was conducted to assess the evidence linking beer consumption to abdominal and general obesity. Following a systematic search strategy, 35 eligible observational studies and 12 experimental studies were identified. Regarding abdominal obesity, most observational data pointed towards a positive association or no association between beer intake and waist circumference or waist-to-hip ratio in men, whereas results for women were inconsistent. Data from a subset of studies indicated that beer intake > 500 mL/day may be positively associated with abdominal obesity. Regarding general obesity, most observational studies pointed towards an inverse association or no association between beer intake and body weight in women and a positive association or no association in men. Data from six experimental studies in men, in which alcoholic beer was compared with low-alcoholic beer, suggested that consumption of alcoholic beer (for 21-126 days) results in weight gain (0.73 kg; P
Originalsprog Engelsk
Tidsskrift Nutrition Reviews
Vol/bind 71
Tidsskriftsnummer 2
Sider (fra-til) 67-87
Antal sider 21
ISSN 0029-6643
DOI
Status Udgivet - feb. 2013

Is increased joint loading detrimental to obese patients with knee osteoarthritis? A secondary data analysis from a randomized trial

Henriksen, M., Hunter, D. J., Dam, E. B., Messier, S. P., Andriacchi, T. P., Lohmander, L. S., Aaboe, J., Boesen, M., Gudbergsen, H., Bliddal, H. & Christensen, R. dec. 2013 I : Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 21, 12, s. 1865-75 11 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

To investigate whether increased knee joint loading due to improved ambulatory function and walking speed following weight loss achieved over 16 weeks accelerates symptomatic and structural disease progression over a subsequent 1 year weight maintenance period in an obese population with knee osteoarthritis (OA).
Originalsprog Engelsk
Tidsskrift Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society
Vol/bind 21
Tidsskriftsnummer 12
Sider (fra-til) 1865-75
Antal sider 11
ISSN 1063-4584
DOI
Status Udgivet - dec. 2013

Knee Arthroscopy Cohort Southern Denmark (KACS): protocol for a prospective cohort study

Thorlund, J. B., Christensen, R., Nissen, N., Jørgensen, U., Schjerning, J., Pørneki, J. C., Englund, M. & Lohmander, L. S. 2013 I : B M J Open. 3, 10, s. e003399

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Meniscus surgery is a high-volume surgery carried out on 1 million patients annually in the USA. The procedure is conducted on an outpatient basis and the patients leave the hospital a few hours after surgery. A critical oversight of previous studies is their failure to account for the type of meniscal tears. Meniscus tears can be categorised as traumatic or non-traumatic. Traumatic tears (TT) are usually observed in younger, more active individuals in an otherwise 'healthy' meniscus and joint. Non-traumatic tears (NTT) (ie, degenerative tears) are typically observed in the middle-aged (35-55 years) and older population but the aetiology is largely unclear. Knowledge about the potential difference of the effect of arthroscopic meniscus surgery on patient symptoms between patients with traumatic and NTT is sparse. Furthermore, little is known about the natural time course of patient perceived pain, function and quality of life after meniscus surgery and factors affecting these outcomes. The aim of this prospective cohort study is to investigate the natural time course of patient-reported outcomes in patients undergoing meniscus surgery, with particular emphasis on the role of type of symptom onset.
Originalsprog Engelsk
Tidsskrift B M J Open
Vol/bind 3
Tidsskriftsnummer 10
Sider (fra-til) e003399
ISSN 2044-6055
DOI
Status Udgivet - 2013

Local administration of insulin-like growth factor-I (IGF-I) stimulates tendon collagen synthesis in humans

Hansen, M., Boesen, A., Holm, L., Flyvbjerg, A., Langberg, H. & Kjaer, M. okt. 2013 I : Scandinavian journal of medicine & science in sports. 23, 5, s. 614-9 6 s.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Collagen is the predominant structural protein in tendons and ligaments, and can be controlled by hormonal changes. In animals, injections of insulin-like growth factor I (IGF-I) has been shown to increase collagen synthesis in tendons and ligaments and to improve structural tissue healing, but the effect of local IGF-I administration on tendon collagen synthesis in human has not been studied. The purpose of this study was to study whether local injections of IGF-I would have a stimulating effect on tendon collagen synthesis. Twelve healthy nonsmoking men [age 62 ± 1 years (mean ± SEM), BMI 27 ± 1] participated. Two injections of either human recombinant IGF-I (0.1 mL Increlex©) or saline (control) into each patellar tendon were performed 24-h apart, respectively. Tendon collagen fractional synthesis rate (FSR) was measured by stable isotope technique in the hours after the second injection. Simultaneously, interstitial peritendinous (IGF-I) and [procollagen type I N-terminal propeptide (PINP)], as a marker for type I collagen synthesis, were determined by microdialysis technique. Tendon collagen FSR and PINP were significantly higher in the IGF-I leg compared with the control leg (P
Originalsprog Engelsk
Tidsskrift Scandinavian journal of medicine & science in sports
Vol/bind 23
Tidsskriftsnummer 5
Sider (fra-til) 614-9
Antal sider 6
ISSN 0905-7188
DOI
Status Udgivet - okt. 2013

Magnetic resonance imaging-assessment of early response to certolizumab pegol in rheumatoid arthritis: A randomized, double-blind, placebo-controlled phase IIIb study applying magnetic resonance imaging at week 0, 1, 2, 4, 8 and 16

Østergaard, M., Jacobsson, L., Schaufelberger, C., Hansen, M. S., Bijlsma, J., Dudek, A., Reel-Bakalarska, M., Staelens, F., Haake, R., Sundman-Engberg, B. & Bliddal, H. 2013 I : Arthritis & Rheumatism. 65, Suppl. 10, s. S842 1 s.

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

Originalsprog Engelsk
Tidsskrift Arthritis & Rheumatism
Vol/bind 65
Tidsskriftsnummer Suppl. 10
Sider (fra-til) S842
Antal sider 1
ISSN 0004-3591
Status Udgivet - 2013

MRI in knee osteoarthritis. Application in diet intervention

Gudbergsen, H. mar. 2013 I : Danish Medical Bulletin (Online). 60, 3, s. B4594

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

This thesis examines two main hypotheses: 1. Obese knee osteoarthritis (KOA) patients can achieve symptomatic improvements following diet intervention regardless of their level of structural damage and overall joint malfunctioning: 2. Rapid weight-loss in obese patients with KOA will lead to improvements in KOA related pathology that can be assessed and evaluated by MRI. Data for the studies were obtained from obese KOA patients who were recruited for a 16 week diet intervention trial, the CAROT-trial (ClinicalTrials.gov identification no.: NCT00655941). Inclusion criteria were age ≥ 50 years, BMI ≥ 30 kg/square metro plus symptomatic and verified KOA. Patients underwent a 16 weeks dietary programme with formula products and counselling. Baseline and week 16 assessments included clinical examinations, MRI and CR of the most symptomatic knee, muscle strength tests, gait analyses, blood samples and collection of patient-reported outcomes with a variety of generic and specific health status questionnaires. MRI scans were graded by the BLOKS and CR was analysed by measuring the mJSW and grading the knee as described by KL. 388 possible subjects were pre-screened, 192 were enrolled. Following the 16 weeks diet intervention 175 patients remained in the study. 187 (97%) MRI scans were completed at baseline, 172 (98 %) MRI scans obtained at week 16 and this left the study with 169 (97%) patients with complete MRI datasets at week 16. No statistical significant differences were detected between baseline characteristics of all the initially included patients (n = 192) and the 169 patients included in the per protocol analyses performed in study III (p 10%) and those who did not. Furthermore, changes in clinical symptoms and BML scores were not associated. The limitations of this thesis were that the MRI analyses were based on single determinations of MRI variables and that the studies did not assess between scan reliability. The MRI protocol for this study did not include all the recommended sequences for BLOKS. Analysing BMLs with the use of only coronal STIR and T1w sequences is considered adequate for a reasonable assessment of the tibial and femoral bones. However, we recognize the limitations this strategy withholds in terms of correctly assessing BMLs located at the margins of our slices when only having a single plane view included in our MRI protocol. Due to an inadequate coverage we did not analyse BMLs in patella, and this confined the thesis to only study changes in the tibial and femoral bones. BLOKS contains separate scores for effusion and synovitis and we have assessed all MRI scans according to this discrimination well knowing that this procedure is biased and that a recent paper has proposed the combination of the two scores. MRI technology allows for an excellent discrimination and delineation of synovitis and synovial effusion by performing MRI with I.V. gadolinium and post-contrast T1 FS images, but due to extensive requirements and longer scans times for such examinations we proceeded with our, in this matter, suboptimal MRI protocol. The optimal assessment of KOA would be achieved by performing three radiographic views, posteroanterior, lateral and skyline, but for this study we chose a radiographic protocol only including the first two mentioned as this procedure was somewhat similar to the routine examination for KOA applied on a daily basis at our Department of Radiology. The results of this thesis support existing guidelines suggesting that diet intervention in obese KOA patients is beneficial for symptomatic improvements. The new information from the thesis is that improvement in clinical symptoms is possible for the majority of patients, independent of their pre-study level of structural damage and measures of joint malfunctioning. The present results also demonstrated that a rapid weight-loss had no association to changes in BML scores and established that changes observed in symptoms and BML scores, following a 16 weeks diet intervention, were not related.
Originalsprog Engelsk
Tidsskrift Danish Medical Bulletin (Online)
Vol/bind 60
Tidsskriftsnummer 3
Sider (fra-til) B4594
ISSN 1603-9629
Status Udgivet - mar. 2013
To investigate relationships between perceived and objectively measured muscle fatigue during exhausting muscle contractions in women with fibromyalgia (FM) compared with healthy controls (HC).
Originalsprog Engelsk
Tidsskrift Annals of the Rheumatic Diseases
Vol/bind 72
Tidsskriftsnummer 6
Sider (fra-til) 963-6
Antal sider 4
ISSN 0003-4967
DOI
Status Udgivet - jun. 2013

Neurologi og Neurorehabilitering

Wæhrens, E. E., Winkel, A. & Jørgensen, H. S. 2013 2 udg. Munksgård Danmark. 544 s.

Publikation: Bog/antologi/afhandling/rapportAntologiForskning

Originalsprog Dansk
Forlag Munksgård Danmark
Vol/bind 1
Udgave 2
Antal sider 544
ISBN (Trykt) 9788762810167
ISBN (Elektronisk) 9788762813380
Status Udgivet - 2013

Non-pharmacological interventions for fatigue in rheumatoid arthritis

Cramp, F., Hewlett, S., Almeida, C., Kirwan, J. R., Choy, E. H., Chalder, T., Pollock, J. & Christensen, R. 2013 I : Cochrane Database of Systematic Reviews. 8, s. CD008322

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Fatigue is a common and potentially distressing symptom for people with rheumatoid arthritis with no accepted evidence based management guidelines. Non-pharmacological interventions, such as physical activity and psychosocial interventions, have been shown to help people with a range of other long-term conditions to manage subjective fatigue.
Originalsprog Engelsk
Tidsskrift Cochrane Database of Systematic Reviews
Vol/bind 8
Sider (fra-til) CD008322
ISSN 1469-493X
DOI
Status Udgivet - 2013
Muscle sound gives a local picture of muscles involved in a particular movement and is independent of electrical signals between nerve and muscle. Sound recording (acoustic myography) is a well-known noninvasive technique that has suffered from not being easily applicable, as well as not being able to register at sufficient sampling speed. With modern amplifiers and digital sound recording this has changed, and such assessment during movement outside a laboratory setting may be possible. Our aim was to develop a setup for muscle-sound assessment, which could be reliably applied in any local setting. A group of healthy subjects were assessed during standing, stair climbing, walking, and running. Piezoelectric microphones were applied to the skin using contact gel. A digital sound recorder enabled sampling speeds of around 96,000 Hz. Surface electromyography was measured in parallel as a comparison. The recorded signals were assessed and described in terms of signal frequency (Hz) and peak-to-peak amplitude (mV) using Chart software. Bioimpedance of the involved muscles was measured. Sound recording was shown to be an easy noninvasive method for assessment of muscle function during movement with the possibility of being applied in most clinical, sports, and home settings. Muscle sound gives a representation of the work of each muscle group during a complex movement, illustrated here by a step test, which revealed both concentric and eccentric activity. The method in the presented new setup has great potential for assessment of function in patients with musculoskeletal complaints in out-of-clinic settings, as well as in sports.
Originalsprog Engelsk
Tidsskrift Physiological Reports
Vol/bind 1
Tidsskriftsnummer 2
Sider (fra-til) e00029
DOI
Status Udgivet - jul. 2013
Originalsprog Engelsk
Tidsskrift Annals of the Rheumatic Diseases
Vol/bind 72
Tidsskriftsnummer Suppl. 3
Sider (fra-til) 758-9
Antal sider 2
ISSN 0003-4967
Status Udgivet - 2013

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